https://doi.org/10.4081/ejh.2020.3143
Prognostic significance of CD133 and ABCB5 expression in papillary thyroid carcinoma
Accepted: 3 November 2020
HTML: 4
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Expression of CD133 and ABCB5 is associated with tumor aggressiveness, but evidence in papillary thyroid cancer (PTC) is lacking. We correlated CD133 and ABCB5 expression with pathological characteristics and factors of worse prognosis in PTC. Samples of 119 PTCs and 40 controls (goiters) were distributed in 8 tissue microarray blocks and evaluated with immunohistochemistry using anti-CD133 and anti-ABCB5 antibodies. The expression of each marker alone and combined was analyzed against pathological characteristics and factors of worse prognosis in PTC. Expression of CD133 alone (19 tumors, 16.0%) was more frequent in patients with versus without lymph node metastases (P=0.024). Expression of ABCB5 alone (n=95, 83.3%) was associated with larger tumor size (P=0.045). CD133-ABCB5 coexpression was not associated with pathological characteristics or factors of worse prognosis in PTC.
Supporting Agencies
Mackenzie Evangelical College of Paraná (Curitiba, Paraná, Brazil), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – Brasil (CAPES)How to Cite
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.
Similar Articles
- Chiara Rita Inguscio, Barbara Cisterna, Maria Assunta Lacavalla, Franco Donati, Osvaldo Angelini, Gabriele Tabaracci, Manuela Malatesta, Ozone and procaine increase secretion of platelet-derived factors in platelet-rich plasma , European Journal of Histochemistry: Vol. 67 No. 4 (2023)
- A Sakar, S Vatansever, L Sepit, K Ozbilgin, A Yorgancioglu1, Effect of recombinant human activated protein C on apoptosis-related proteins , European Journal of Histochemistry: Vol. 51 No. 2 (2007)
- F. Dorko, D. Kluchová, A. Boleková, K. Lovasová, T. Špakovská, T. Borošová, Influence of surgical and chemical orchidectomy on weight and distribution of AChE-nerve fibres in thymuses of adult rats , European Journal of Histochemistry: Vol. 55 No. 3 (2011)
- A. Di Giancamillo, M.E. Andreis, P. Taini, M.C. Veronesi, M. Di Giancamillo, S.C. Modina, Cartilage canals in newborn dogs: histochemical and immunohistochemical findings , European Journal of Histochemistry: Vol. 60 No. 3 (2016)
- Daša Zupančič, Rok Romih, Immunohistochemistry as a paramount tool in research of normal urothelium, bladder cancer and bladder pain syndrome , European Journal of Histochemistry: Vol. 65 No. 2 (2021)
- D Fanni, L Pilloni, S Orrù, P Coni, Expression of ATP7B in normal human liver , European Journal of Histochemistry: Vol. 49 No. 4 (2005)
- E Wyroba, L Surmacz, M Osinska, J Wiejak, Phagosome maturation in unicellular eukaryote Paramecium: the presence of RILP, Rab7 and LAMP-2 homologues , European Journal of Histochemistry: Vol. 51 No. 3 (2007)
- L Benkoël, P Biagini, F Dodero, X De Lamballerie, P De Micco, A Chamlian, D Lombardo, Immunohistochemical detection of C-100 hepatitis C virus antigen in formaldehyde-fixed paraffin-embedded liver tissue. Correlation with serum, tissue and in situ RT-PCR results , European Journal of Histochemistry: Vol. 48 No. 2 (2004)
- ChenHui Zhu, LiJuan Lin, ChangQing Huang, ZhiHui Wu, Activation of Hedgehog pathway by circEEF2/miR-625-5p/TRPM2 axis promotes prostate cancer cell proliferation through mitochondrial stress , European Journal of Histochemistry: Vol. 68 No. 4 (2024)
- S Montagnani, L Postiglione, G Giordano-Lanza, F Di Meglio, C Castaldo, S Sciorio, N Montuori, G Di Spigna, P Ladogana, A Oriente, G Rossi, Granulocyte macrophage colony stimulating factor (GM-CSF) biological actions on human dermal fibroblasts , European Journal of Histochemistry: Vol. 45 No. 3 (2001)
<< < 46 47 48 49 50 51 52 53 54 55 > >>
You may also start an advanced similarity search for this article.
