https://doi.org/10.4081/ejh.2020.3143
Prognostic significance of CD133 and ABCB5 expression in papillary thyroid carcinoma
Accepted: 3 November 2020
HTML: 4
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Expression of CD133 and ABCB5 is associated with tumor aggressiveness, but evidence in papillary thyroid cancer (PTC) is lacking. We correlated CD133 and ABCB5 expression with pathological characteristics and factors of worse prognosis in PTC. Samples of 119 PTCs and 40 controls (goiters) were distributed in 8 tissue microarray blocks and evaluated with immunohistochemistry using anti-CD133 and anti-ABCB5 antibodies. The expression of each marker alone and combined was analyzed against pathological characteristics and factors of worse prognosis in PTC. Expression of CD133 alone (19 tumors, 16.0%) was more frequent in patients with versus without lymph node metastases (P=0.024). Expression of ABCB5 alone (n=95, 83.3%) was associated with larger tumor size (P=0.045). CD133-ABCB5 coexpression was not associated with pathological characteristics or factors of worse prognosis in PTC.
Supporting Agencies
Mackenzie Evangelical College of Paraná (Curitiba, Paraná, Brazil), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – Brasil (CAPES)How to Cite
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.
Similar Articles
- EIC Beltrão, PL Medeiros, OG Rodrigues, J Figueredo-Silva, MM Valença, LCBB Coelho, LB Carvalho, Parkia pendula lectin as histochemistry marker for meningothelial tumour , European Journal of Histochemistry: Vol. 47 No. 2 (2003)
- R Cardani, E Mancinelli, G Rotondo, V Sansone, G Meola, Muscleblind-like protein 1 nuclear sequestration is a molecular pathology marker of DM1 and DM2 , European Journal of Histochemistry: Vol. 50 No. 3 (2006)
- Giovanni Li Volti, The Chaperonopathies - Diseases with Defective Molecular Chaperones , European Journal of Histochemistry: Vol. 57 No. 4 (2013)
- Francesca Scolari, Alessandro Girella, Anna Cleta Croce, Imaging and spectral analysis of autofluorescence patterns in larval head structures of mosquito vectors , European Journal of Histochemistry: Vol. 66 No. 4 (2022)
- MG Rambotti, S Simonetti, A Spreca, PACAP activated adenylate cyclase in human sweat glands. An ultracytochemical study , European Journal of Histochemistry: Vol. 46 No. 3 (2002)
- CarloAlberto Redi, Mouse cell culture - Methods and protocols , European Journal of Histochemistry: Vol. 54 No. 4 (2010)
- Carlo Alberto Redi, Human pluripotent stem cells , European Journal of Histochemistry: Vol. 56 No. 3 (2012)
- Carlo Pellicciari, Histochemistry today: Detection and location of single molecules , European Journal of Histochemistry: Vol. 61 No. 4 (2017)
- G Anastasi, G Cutroneo, G Rizzo, A Arco, G Santoro, P Bramanti, AG Vitetta, A Pisani, F Trimarchi, A Favaloro, Sarcoglycan and integrin localization in normal human skeletal muscle: a confocal laser scanning microscope study , European Journal of Histochemistry: Vol. 48 No. 3 (2004)
- A Licata, A Mauceri, L Ainis, S Martella, MB Ricca, P Licata, A Amato, Lectin histochemistry of epidermal glandular cells in the earthworm Lumbricus terrestris (Annelida Oligochaeta) , European Journal of Histochemistry: Vol. 46 No. 2 (2002)
<< < 63 64 65 66 67 68 69 70 71 72 > >>
You may also start an advanced similarity search for this article.
