https://doi.org/10.4081/ejh.2020.3143
Prognostic significance of CD133 and ABCB5 expression in papillary thyroid carcinoma
Accepted: 3 November 2020
HTML: 4
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Expression of CD133 and ABCB5 is associated with tumor aggressiveness, but evidence in papillary thyroid cancer (PTC) is lacking. We correlated CD133 and ABCB5 expression with pathological characteristics and factors of worse prognosis in PTC. Samples of 119 PTCs and 40 controls (goiters) were distributed in 8 tissue microarray blocks and evaluated with immunohistochemistry using anti-CD133 and anti-ABCB5 antibodies. The expression of each marker alone and combined was analyzed against pathological characteristics and factors of worse prognosis in PTC. Expression of CD133 alone (19 tumors, 16.0%) was more frequent in patients with versus without lymph node metastases (P=0.024). Expression of ABCB5 alone (n=95, 83.3%) was associated with larger tumor size (P=0.045). CD133-ABCB5 coexpression was not associated with pathological characteristics or factors of worse prognosis in PTC.
Supporting Agencies
Mackenzie Evangelical College of Paraná (Curitiba, Paraná, Brazil), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – Brasil (CAPES)How to Cite
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.
Similar Articles
- G Anastasi, G Cutroneo, G Santoro, A Arco, G Rizzo, C Trommino, P Bramanti, Integrins, muscle agrin and sarcoglycans during muscular inactivity conditions: an immunohistochemical study , European Journal of Histochemistry: Vol. 50 No. 4 (2006)
- C Pellicciari, MG Bottone, AI Scovassi, TE Martin, M Biggiogera, Rearrangement of nuclear ribonucleoproteins and extrusion of nucleolus-like bodies during apoptosis induced by hypertonic stress , European Journal of Histochemistry: Vol. 44 No. 3 (2000)
- Marco Biggiogera, Manuela Malatesta, In memoriam of Prof. Stan Fakan , European Journal of Histochemistry: Vol. 67 No. 1 (2023)
- E Bonanno, G Tagliafierro, EC Carlà, MR Montinari, P Pagliara, G Mascetti, LG Spagnoli, L Dini, Synchronized onset of nuclear and cell surface modifications in U937 cells during apoptosis , European Journal of Histochemistry: Vol. 46 No. 1 (2002)
- CJ Woodall, DI Graham, Evidence for neuronal localisation of enteroviral sequences in motor neurone disease/amyotrophic lateral sclerosis by in situ hybridization , European Journal of Histochemistry: Vol. 48 No. 2 (2004)
- Antonella Vetuschi, Simona Pompili, Gian Piero Di Marco, Federico Calvaruso, Enzo Iacomino, Lidia Angelosante, Claudio Festuccia, Alessandro Colapietro, Roberta Sferra, Can the AGE/RAGE/ERK signalling pathway and the epithelial-to-mesenchymal transition interact in the pathogenesis of chronic rhinosinusitis with nasal polyps? , European Journal of Histochemistry: Vol. 64 No. 1 (2020)
- M Trovato, M Grosso, E Vitarelli, M Le Donne, V Barresi, F Trimarchi, G Barresi, Immunoexpression of CD30 and CD30 ligand in deciduas from spontaneous abortions , European Journal of Histochemistry: Vol. 49 No. 3 (2005)
- MF Izaguirre, A Peralta Soler, VH Casco, Expression of N-CAM-180 and N-Cadherin during development in two southamerican anuran species (Bufo arenarum and Hyla nana) , European Journal of Histochemistry: Vol. 44 No. 4 (2000)
- PY Scaraffia, C Maldonado, A Aoki, NM Gerez De Burgos, Comparative study of enzymes in testes and ovaries from adult Dipetalogaster maximus (Uhler) and Triatoma infestans (Klug) (Hemiptera: Reduviidae). Correlation with fine structural organization , European Journal of Histochemistry: Vol. 45 No. 3 (2001)
- J. Zhang, J. Luo, J. Ni, L. Tang, H.P. Zhang, L. Zhang, J.F. Xu, D. Zheng, Erratum - MMP-7 is upregulated by COX-2 and promotes proliferation and invasion of lung adenocarcinoma cells , European Journal of Histochemistry: Vol. 68 No. 3 (2024)
<< < 69 70 71 72 73 74 75 76 77 78 > >>
You may also start an advanced similarity search for this article.
