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β-catenin mediates the effect of GLP-1 receptor agonist on ameliorating hepatic steatosis induced by high fructose diet

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The hypoglycemic drug GLP-1 receptor agonist can ameliorate hepatic steatosis but the mechanism is not clear. Intake of high fructose leads to non-alcoholic fatty liver disease by stimulating lipid synthesis, and β-catenin is the key molecule for realizing GLP-1 function in extrahepatic tissues; with the discovery of GLP-1 receptor in liver, we speculate that β-catenin might mediate GLP-1 receptor agonist on ameliorating hepatic steatosis induced by high fructose. Wistar rats were fed with high fructose diet for 8 weeks and then treated with GLP-1 receptor agonist exenatide for 4 weeks; the changes of lipid synthesis pathway factors, the expression and nuclear translocation of β-catenin, and the hepatic steatosis of the rats were observed. After the intervention of exenatide, the hepatic steatosis induced by high fructose was improved, the nuclear translocation and expression of β-catenin were facilitated, and the mRNA and protein expression of the upstream regulator SREBP-1 and the downstream key enzymes ACC, FAS and SCD-1 of de novo lipogenesis were down-regulated. GLP-1 receptor agonist may ameliorate hepatic steatosis induced by high fructose by β-catenin regulating de novo lipogenesis pathway. GLP-1 receptor agonist may be a potential new drug for the treatment of non-alcoholic fatty liver disease, and the β-catenin may be an important target for the drug therapy.

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Haoran Jiang, Linquan Zang (2024)
GLP-1/GLP-1RAs: New Options for the Drug Treatment of NAFLD. Current Pharmaceutical Design, 30(2), 100.
10.2174/0113816128283153231226103218
玉婷 黎 (2024)
Research Progress on Hyperinsulinemia and Insulin Resistance. Hans Journal of Biomedicine, 14(03), 353.
10.12677/hjbm.2024.143039
Olfa Khalifa, Neyla S. AL-Akl, Khaoula Errafii, Abdelilah Arredouani (2022)
Exendin-4 alleviates steatosis in an in vitro cell model by lowering FABP1 and FOXA1 expression via the Wnt/-catenin signaling pathway. Scientific Reports, 12(1),
10.1038/s41598-022-06143-5
Amany E. Nofal, Hind S. AboShabaan, Walaa A. Fadda, Rafik E. Ereba, Sherin M. Elsharkawy, Heba M. Hathout (2024)
L-carnitine and Ginkgo biloba Supplementation In Vivo Ameliorates HCD-Induced Steatohepatitis and Dyslipidemia by Regulating Hepatic Metabolism. Cells, 13(9), 732.
10.3390/cells13090732
Basile Njei, Yazan Al-Ajlouni, Samira Y Lemos, Derek Ugwendum, Prince Ameyaw, Lea-Pearl Njei, Sarpong Boateng (2024)
Efficacy and Safety of GLP-1 Receptor Agonists in Patients With Metabolic Dysfunction-Associated Steatotic Liver Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Cureus,
10.7759/cureus.71366
Ranran Zhang, Hongna Mu, Ziyun Li, Jie Zeng, Qi Zhou, Hongxia Li, Siming Wang, Xianghui Li, Xianghui Zhao, Liang Sun, Wenxiang Chen, Jun Dong, Ruiyue Yang (2022)
Oral administration of branched-chain amino acids ameliorates high-fat diet-induced metabolic-associated fatty liver disease via gut microbiota-associated mechanisms. Frontiers in Microbiology, 13,
10.3389/fmicb.2022.920277
María Cecilia Castro, Hernán Gonzalo Villagarcía, Guillermo Schinella, María Laura Massa, Flavio Francini (2023)
Mechanism of preventive effects of exendin-4 and des-fluoro-sitagliptin in a murine model of fructose-induced prediabetes. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1868(9), 159363.
10.1016/j.bbalip.2023.159363
Olfa Khalifa, Kamal H. Mroue, Raghvendra Mall, Ehsan Ullah, Nayla S. Al-Akl, Abdelilah Arredouani (2022)
Investigation of the Effect of Exendin-4 on Oleic Acid-Induced Steatosis in HepG2 Cells Using Fourier Transform Infrared Spectroscopy. Biomedicines, 10(10), 2652.
10.3390/biomedicines10102652
Manuel Alejandro Vargas-Vargas, Marcela González-Montoya, Olin Torres-Isidro, Claudia Isabel García-Berumen, Omar Ortiz-Avila, Elizabeth Calderón-Cortés, Christian Cortés-Rojo (2024)
Assessing the impact of concurrent high-fructose and high-saturated fat diets on pediatric metabolic syndrome: A review. World Journal of Clinical Pediatrics, 13(2),
10.5409/wjcp.v13.i2.91478
Mareca Lodge, Rachel Dykes, Arion Kennedy (2024)
Regulation of Fructose Metabolism in Nonalcoholic Fatty Liver Disease. Biomolecules, 14(7), 845.
10.3390/biom14070845
Volodymyr V. Balatskyi, Adrian Sowka, Pawel Dobrzyn, Oksana O. Piven (2023)
WNT/β‐catenin pathway is a key regulator of cardiac function and energetic metabolism. Acta Physiologica, 237(3),
10.1111/apha.13912

Ethics Approval

The study was approved by the Animal Ethics Committee of Hebei General Hospital

How to Cite

Gao, Z. ., Song, G.-Y., Ren, L.-P. ., Ma, H.-J. ., Ma, B.-Q. ., & Chen, S.-C. . (2020). β-catenin mediates the effect of GLP-1 receptor agonist on ameliorating hepatic steatosis induced by high fructose diet. European Journal of Histochemistry, 64(3). https://doi.org/10.4081/ejh.2020.3160

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