LncRNA GClnc1 may contribute to the progression of ovarian cancer by regulating p53 signaling pathway

Hu Li; Zheng Zeng; Xiang Yang; Ye Chen; Lei He; Ting Wan

doi:10.4081/ejh.2020.3166

Authors

Hu Li

Department of Gynecology; Cancer Institute of Panyu Central Hospital, Guangzhou, China.

Zheng Zeng

Department of Gynecology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Xiang Yang

Department of Gynecology, Panyu Central Hospital, Guangzhou, China.

Ye Chen

Department of Gynecology, Panyu Central Hospital, Guangzhou, China.

Lei He

helei33@mail.sysu.edu.cn

https://orcid.org/0000-0003-2573-4302

Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.

Ting Wan

Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.

Ovarian cancer (OC) is one of the most prevalent and deadly types of gynecological malignancy. Since current treatments are not effective against OC, it is imperative to develop novel potential therapeutic targets for managing OC. In this study, we aimed to uncover the underlying molecular mechanism of long non-coding RNA (lncRNA) GClnc1 related to p53 signaling pathway in OC. The expression of lncRNA H19 GClnc1 was markedly higher in OC samples than the related normal tissues. Next, we found that lncRNA GClnc1 inhibited p53. In addition, the lncRNA GClnc1 overexpression promoted the cell proliferation and migration in vitro. Subsequently, p53 silencing obligated the effect of lncRNA GCln1 knock down on cell proliferation and migration. To sum up, LncRNA GClnc1 contributes to the progression of OC by regulating p53 signaling pathway. Meanwhile, our findings also suggested that lncRNA GClnc1 may serve as a novel therapeutic target for OC patients.

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How to Cite

Li, H., Zeng, Z., Yang, X., Chen, Y., He, L., & Wan, T. (2020). LncRNA GClnc1 may contribute to the progression of ovarian cancer by regulating p53 signaling pathway. European Journal of Histochemistry, 64(4). https://doi.org/10.4081/ejh.2020.3166

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