https://doi.org/10.4081/ejh.2020.3166
LncRNA GClnc1 may contribute to the progression of ovarian cancer by regulating p53 signaling pathway
Accepted: 4 September 2020
HTML: 7
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Ovarian cancer (OC) is one of the most prevalent and deadly types of gynecological malignancy. Since current treatments are not effective against OC, it is imperative to develop novel potential therapeutic targets for managing OC. In this study, we aimed to uncover the underlying molecular mechanism of long non-coding RNA (lncRNA) GClnc1 related to p53 signaling pathway in OC. The expression of lncRNA H19 GClnc1 was markedly higher in OC samples than the related normal tissues. Next, we found that lncRNA GClnc1 inhibited p53. In addition, the lncRNA GClnc1 overexpression promoted the cell proliferation and migration in vitro. Subsequently, p53 silencing obligated the effect of lncRNA GCln1 knock down on cell proliferation and migration. To sum up, LncRNA GClnc1 contributes to the progression of OC by regulating p53 signaling pathway. Meanwhile, our findings also suggested that lncRNA GClnc1 may serve as a novel therapeutic target for OC patients.
How to Cite
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.
Similar Articles
- A. Makowiecka, A. Simiczyjew, D. Nowak, A.J. Mazur, Varying effects of EGF, HGF and TGFβ on formation of invadopodia and invasiveness of melanoma cell lines of different origin , European Journal of Histochemistry: Vol. 60 No. 4 (2016)
- M. Hinken, S. Halwachs, C. Kneuer, W. Honscha, Subcellular localization and distribution of the reduced folate carrier in normal rat tissues , European Journal of Histochemistry: Vol. 55 No. 1 (2011)
- Kazuhiko Hashimoto, Shunji Nishimura, Tomohiko Ito, Ryosuke Kakinoki, Masao Akagi, Immunohistochemical expression and clinicopathological assessment of PD-1, PD-L1, NY-ESO-1, and MAGE-A4 expression in highly aggressive soft tissue sarcomas , European Journal of Histochemistry: Vol. 66 No. 2 (2022)
- Alimu Keremu, Pazila Aila, Aikebaier Tusun , Maimaitiaili Abulikemu, Xiaoguang Zou, Extracellular vesicles from bone mesenchymal stem cells transport microRNA-206 into osteosarcoma cells and target NRSN2 to block the ERK1/2-Bcl-xL signaling pathway , European Journal of Histochemistry: Vol. 66 No. 3 (2022)
- Manuel Scimeca, Simone Bischetti, Harpreet Kaur Lamsira, Rita Bonfiglio, Elena Bonanno, Energy Dispersive X-ray (EDX) microanalysis: A powerful tool in biomedical research and diagnosis , European Journal of Histochemistry: Vol. 62 No. 1 (2018)
- Lan Wang, Zhenyu Fan, Haijin Wang, Shougui Xiang, Propofol alleviates M1 polarization and neuroinflammation of microglia in a subarachnoid hemorrhage model in vitro, by targeting the miR-140-5p/TREM-1/NF-κB signaling axis , European Journal of Histochemistry: Vol. 68 No. 3 (2024)
- F. Rappa, E. Unti, P. Baiamonte, F. Cappello, N. Scibetta, Different immunohistochemical levels of Hsp60 and Hsp70 in a subset of brain tumors and putative role of Hsp60 in neuroepithelial tumorigenesis , European Journal of Histochemistry: Vol. 57 No. 2 (2013)
- A. Galia, A.E. Calogero, R. Condorelli, F. Fraggetta, A. La Corte, F. Ridolfo, P. Bosco, R. Castiglione, M. Salemi, PARP-1 protein expression in glioblastoma multiforme , European Journal of Histochemistry: Vol. 56 No. 1 (2012)
- Yangying Peng, Shaojie Ding, Ping Xu, Xueyan Zhang, Jianzhang Wang, Tiantian Li, Liyun Liao, Xinmei Zhang, CCL18 promotes endometriosis by increasing endometrial cell migration and neuroangiogenesis , European Journal of Histochemistry: Vol. 68 No. 3 (2024)
- D. Nowak, A. J. Mazur, A. Popow-Woźniak, A. Radwańska, H. G. Mannherz, M. Malicka-Błaszkiewicz, Subcellular distribution and expression of cofilin and ezrin in human colon adenocarcinoma cell lines with different metastatic potential , European Journal of Histochemistry: Vol. 54 No. 2 (2010)
<< < 5 6 7 8 9 10 11 12 13 14 > >>
You may also start an advanced similarity search for this article.
