https://doi.org/10.4081/ejh.2020.3166
LncRNA GClnc1 may contribute to the progression of ovarian cancer by regulating p53 signaling pathway
Accepted: 4 September 2020
HTML: 7
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Ovarian cancer (OC) is one of the most prevalent and deadly types of gynecological malignancy. Since current treatments are not effective against OC, it is imperative to develop novel potential therapeutic targets for managing OC. In this study, we aimed to uncover the underlying molecular mechanism of long non-coding RNA (lncRNA) GClnc1 related to p53 signaling pathway in OC. The expression of lncRNA H19 GClnc1 was markedly higher in OC samples than the related normal tissues. Next, we found that lncRNA GClnc1 inhibited p53. In addition, the lncRNA GClnc1 overexpression promoted the cell proliferation and migration in vitro. Subsequently, p53 silencing obligated the effect of lncRNA GCln1 knock down on cell proliferation and migration. To sum up, LncRNA GClnc1 contributes to the progression of OC by regulating p53 signaling pathway. Meanwhile, our findings also suggested that lncRNA GClnc1 may serve as a novel therapeutic target for OC patients.
How to Cite
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.
Similar Articles
- A. Busato, P. Fumene Feruglio, P.P. Parnigotto, P. Marzola, A. Sbarbati, In vivo imaging techniques: a new era for histochemical analysis , European Journal of Histochemistry: Vol. 60 No. 4 (2016)
- Zhijiang Chen, Huili Wang, Bin Hu, Xinxin Chen, Meiyu Zheng, Lili Liang, Juanjuan Lyu, Qiyi Zeng, Transcription factor nuclear factor erythroid 2 p45-related factor 2 (NRF2) ameliorates sepsis-associated acute kidney injury by maintaining mitochondrial homeostasis and improving the mitochondrial function , European Journal of Histochemistry: Vol. 66 No. 3 (2022)
- Jacopo J.V. Branca, Donatello Carrino, Ferdinando Paternostro, Massimo Gulisano, Matteo Becatti, Lorenzo Di Cesare Mannelli, Alessandra Pacini, Antioxidant support to ameliorate the oxaliplatin-dependent microglial alteration: morphological and molecular study , European Journal of Histochemistry: Vol. 65 No. s1 (2021): Special Collection on Advances in Neuromorphology in Health and Disease
- A. Di Vito, E. Scali, G. Ferraro, C. Mignogna, I. Presta, C. Camastra, C. Palmieri, G. Donato, T. Barni, Elastofibroma dorsi: a histochemical and immunohistochemical study , European Journal of Histochemistry: Vol. 59 No. 1 (2015)
- Martha I. Dávila-Rodríguez, Elva I. Cortés-Gutiérrez, Roberto Hernández-Valdés, Karla Guzmán-Cortés, Rosa E. De León-Cantú, Ricardo M. Cerda-Flores, Enrique Báez-De la Fuente, DNA damage in acute myeloid leukemia patients of Northern Mexico , European Journal of Histochemistry: Vol. 61 No. 4 (2017)
- Y. Zhu, D. Ning, F. Wang, C. Liu, Y. Xu, X. Jia, D. Zhu, Effect of thyroxine on munc-18 and syntaxin-1 expression in dorsal hippocampus of adult-onset hypothyroid rats , European Journal of Histochemistry: Vol. 56 No. 2 (2012)
- Flavia Carton, Manuela Malatesta, Assessing the interactions between nanoparticles and biological barriers in vitro: a new challenge for microscopy techniques in nanomedicine , European Journal of Histochemistry: Vol. 66 No. 4 (2022)
- Y. Zhang, J. Wang, X. Cheng, B. Yi, X. Zhang, Q. Li, Apigenin induces dermal collagen synthesis via smad2/3 signaling pathway , European Journal of Histochemistry: Vol. 59 No. 2 (2015)
- Zhi Wang, Guihua Jian, Teng Chen, Yiping Chen, Junhui Li, Niansong Wang, The Qi-Bang-Yi-Shen formula ameliorates renal dysfunction and fibrosis in rats with diabetic kidney disease via regulating PI3K/AKT, ERK and PPARγ signaling pathways , European Journal of Histochemistry: Vol. 67 No. 1 (2023)
- Kazuhiko Hashimoto, Shunji Nishimura, Yu Shinyashiki, Tomohiko Ito, Ryosuke Kakinoki, Masao Akagi, Clinicopathological assessment of PD-1/PD-L1 immune checkpoint expression in desmoid tumors , European Journal of Histochemistry: Vol. 67 No. 2 (2023)
<< < 11 12 13 14 15 16 17 18 19 20 > >>
You may also start an advanced similarity search for this article.
