https://doi.org/10.4081/ejh.2020.3166
LncRNA GClnc1 may contribute to the progression of ovarian cancer by regulating p53 signaling pathway
Accepted: 4 September 2020
HTML: 7
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Ovarian cancer (OC) is one of the most prevalent and deadly types of gynecological malignancy. Since current treatments are not effective against OC, it is imperative to develop novel potential therapeutic targets for managing OC. In this study, we aimed to uncover the underlying molecular mechanism of long non-coding RNA (lncRNA) GClnc1 related to p53 signaling pathway in OC. The expression of lncRNA H19 GClnc1 was markedly higher in OC samples than the related normal tissues. Next, we found that lncRNA GClnc1 inhibited p53. In addition, the lncRNA GClnc1 overexpression promoted the cell proliferation and migration in vitro. Subsequently, p53 silencing obligated the effect of lncRNA GCln1 knock down on cell proliferation and migration. To sum up, LncRNA GClnc1 contributes to the progression of OC by regulating p53 signaling pathway. Meanwhile, our findings also suggested that lncRNA GClnc1 may serve as a novel therapeutic target for OC patients.
How to Cite
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.
Similar Articles
- A. Mangas, J. Yajeya, N. González, S. Duleu, M. Geffard, R. Coveñas, NO-tryptophan: a new small molecule located in the rat brain , European Journal of Histochemistry: Vol. 60 No. 3 (2016)
- Z Kalnina, K Silina, R Bruvere, N Gabruseva, A Stengrevics, S Barnikol-Watanabe, M Leja, A Line, Molecular characterisation and expression analysis of SEREX-defined antigen NUCB2 in gastric epithelium, gastritis and gastric cancer , European Journal of Histochemistry: Vol. 53 No. 1 (2009)
- Elena Casiraghi, Mara Cossa, Veronica Huber, Licia Rivoltini, Matteo Tozzi, Antonello Villa, Barbara Vergani, MIAQuant, a novel system for automatic segmentation, measurement, and localization comparison of different biomarkers from serialized histological slices , European Journal of Histochemistry: Vol. 61 No. 4 (2017)
- CarloAlberto Redi, Light microscopy - Methods and protocols , European Journal of Histochemistry: Vol. 55 No. 4 (2011)
- Carlo Alberto Redi, Genetically modified organisms and genetic engineering in research and therapy , European Journal of Histochemistry: Vol. 56 No. 4 (2012)
- M. Úbeda-Manzanaro, J.B. Ortiz-Delgado, C. Sarasquete, The Bromodomain testis-specific gene (Brdt) characterization and expression in gilthead seabream, Sparus aurata, and European seabass, Dicentrarchus labrax , European Journal of Histochemistry: Vol. 60 No. 2 (2016)
- C. Dall'Oca, T. Maluta, F. Cavani, G.P. Morbioli, P. Bernardi, A. Sbarbati, D. Degl'Innocenti, B. Magnan, The biocompatibility of porous vs non-porous bone cements: a new methodological approach , European Journal of Histochemistry: Vol. 58 No. 2 (2014)
- Liuchang Feng, Zaoqiang Lin, Zeyong Tang, Lin Zhu, Shu Xu, Xi Tan, Xinyuan Wang, Jianling Mai, Qinxiang Tan, Emodin improves renal fibrosis in chronic kidney disease by regulating mitochondrial homeostasis through the mediation of peroxisome proliferator-activated receptor-gamma coactivator-1 alpha (PGC-1α) , European Journal of Histochemistry: Vol. 68 No. 2 (2024)
- N. Kiga, I. Tojyo, T. Matsumoto, Y. Hiraishi, Y. Shinohara, S. Fujita, Expression of lumican related to CD34 and VEGF in the articular disc of the human temporomandibular joint. , European Journal of Histochemistry: Vol. 54 No. 3 (2010)
- Carlo Alberto Redi, Protein expression in mammalian cells: methods and protocols , European Journal of Histochemistry: Vol. 56 No. 3 (2012)
<< < 27 28 29 30 31 32 33 34 35 36 > >>
You may also start an advanced similarity search for this article.
