https://doi.org/10.4081/ejh.2020.3166
LncRNA GClnc1 may contribute to the progression of ovarian cancer by regulating p53 signaling pathway
Accepted: 4 September 2020
HTML: 7
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Ovarian cancer (OC) is one of the most prevalent and deadly types of gynecological malignancy. Since current treatments are not effective against OC, it is imperative to develop novel potential therapeutic targets for managing OC. In this study, we aimed to uncover the underlying molecular mechanism of long non-coding RNA (lncRNA) GClnc1 related to p53 signaling pathway in OC. The expression of lncRNA H19 GClnc1 was markedly higher in OC samples than the related normal tissues. Next, we found that lncRNA GClnc1 inhibited p53. In addition, the lncRNA GClnc1 overexpression promoted the cell proliferation and migration in vitro. Subsequently, p53 silencing obligated the effect of lncRNA GCln1 knock down on cell proliferation and migration. To sum up, LncRNA GClnc1 contributes to the progression of OC by regulating p53 signaling pathway. Meanwhile, our findings also suggested that lncRNA GClnc1 may serve as a novel therapeutic target for OC patients.
How to Cite
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.
Similar Articles
- E.P. Carvalho-Filho, A.C. Stabile, E. Ervolino, M.B.S. Stuani, M.M. Iyomasa, M.J.A. Rocha, Celecoxib treatment does not alter recruitment and activation of osteoclasts in the initial phase of experimental tooth movement , European Journal of Histochemistry: Vol. 56 No. 4 (2012)
- Eetmad A. Arafat, Eman M.I. Youssef, Hanaa A. Khalaf, The possible alleviating effect of garlic supplement on the neural retina in a rat model of hypercholesterolemia: a histological and immunohistochemical study , European Journal of Histochemistry: Vol. 65 No. 4 (2021)
- E.V. Seliverstova, N.P. Prutskova, Receptor-mediated endocytosis of lysozyme in renal proximal tubules of the frog Rana temporaria , European Journal of Histochemistry: Vol. 59 No. 2 (2015)
- D. Stępiński, Immunofluorescent localization of ubiquitin and proteasomes in nucleolar vacuoles of soybean root meristematic cells , European Journal of Histochemistry: Vol. 56 No. 2 (2012)
- C. Loreto, A. Psaila, G. Musumeci, S. Castorina, R. Leonardi, Apoptosis activation in human carious dentin. An immunohistochemical study , European Journal of Histochemistry: Vol. 59 No. 3 (2015)
- L. Vinci, A. Ravarino, V. Fanos, A.G. Naccarato, G. Senes, C. Gerosa, G. Bevilacqua, G. Faa, R. Ambu, Immunohistochemical markers of neural progenitor cells in the early embryonic human cerebral cortex , European Journal of Histochemistry: Vol. 60 No. 1 (2016)
- Hao Li, Junliang Chen, Wenjun You, Yizhen Xu, Yaqiong Ye, Haiquan Zhao, Junxing Li, Hui Zhang, Developmental characteristics of cutaneous telocytes in late embryos of the silky fowl , European Journal of Histochemistry: Vol. 68 No. 4 (2024)
- M.L. Escobar, O.M. EcheverrÃa, G. GarcÃa, R. OrtÃz, G.H. Vázquez-Nin, Immunohistochemical and ultrastructural study of the lamellae of oocytes in atretic follicles in relation to different processes of cell death , European Journal of Histochemistry: Vol. 59 No. 3 (2015)
- J. Knabl, A. Vattai, R. Hüttenbrenner, S. Hutter, M. Karsten, U. Jeschke, RXRα is upregulated in first trimester endometrial glands of spontaneous abortions unlike LXR and PPARγ , European Journal of Histochemistry: Vol. 60 No. 4 (2016)
- Yunlong Zhang, Xin He, Jianyu Zou, Jie Yang, Ao Ma, Minghui Tan, Phosphorylation mutation impairs the promoting effect of spastin on neurite outgrowth without affecting its microtubule severing ability , European Journal of Histochemistry: Vol. 67 No. 1 (2023)
<< < 29 30 31 32 33 34 35 36 37 38 > >>
You may also start an advanced similarity search for this article.
