https://doi.org/10.4081/ejh.2020.3166
LncRNA GClnc1 may contribute to the progression of ovarian cancer by regulating p53 signaling pathway
Accepted: 4 September 2020
HTML: 7
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Ovarian cancer (OC) is one of the most prevalent and deadly types of gynecological malignancy. Since current treatments are not effective against OC, it is imperative to develop novel potential therapeutic targets for managing OC. In this study, we aimed to uncover the underlying molecular mechanism of long non-coding RNA (lncRNA) GClnc1 related to p53 signaling pathway in OC. The expression of lncRNA H19 GClnc1 was markedly higher in OC samples than the related normal tissues. Next, we found that lncRNA GClnc1 inhibited p53. In addition, the lncRNA GClnc1 overexpression promoted the cell proliferation and migration in vitro. Subsequently, p53 silencing obligated the effect of lncRNA GCln1 knock down on cell proliferation and migration. To sum up, LncRNA GClnc1 contributes to the progression of OC by regulating p53 signaling pathway. Meanwhile, our findings also suggested that lncRNA GClnc1 may serve as a novel therapeutic target for OC patients.
How to Cite
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.
Similar Articles
- Yuejuan Cao, Li Cui, Shaoyong Tuo, Hongze Liu, Shaonan Cui, Resveratrol mediates mitochondrial function through the sirtuin 3 pathway to improve abnormal metabolic remodeling in atrial fibrillation , European Journal of Histochemistry: Vol. 68 No. 2 (2024)
- I. Ferrandino, R. Favorito, M. C. Grimaldi, Cadmium induces changes on ACTH and PRL cells in Podarcis sicula Lizard pituitary gland , European Journal of Histochemistry: Vol. 54 No. 4 (2010)
- I. Janiuk, I. Kasacka, Quantitative evaluation of CART-containing cells in urinary bladder of rats with renovascular hypertension , European Journal of Histochemistry: Vol. 59 No. 2 (2015)
- E. Fantinato, L. Milani, G. Sironi, Sox9 expression in canine epithelial skin tumors , European Journal of Histochemistry: Vol. 59 No. 3 (2015)
- Enrica Cappellozza, Federico Boschi, Maddalena Sguizzato, Elisabetta Esposito, Rita Cortesi, Manuela Malatesta, Laura Calderan, A spectrofluorometric analysis to evaluate transcutaneous biodistribution of fluorescent nanoparticulate gel formulations , European Journal of Histochemistry: Vol. 66 No. 1 (2022)
- N. Accart, J. Dawson, F. Kolbinger, I. Kramer, N. Beckmann, Non-invasive imaging demonstrates clinical features of ankylosing spondylitis in a rat adjuvant model: a case study , European Journal of Histochemistry: Vol. 60 No. 4 (2016)
- Zeqi Tang, Xiaojie Yuan, Yuming Bai, Yiming Guo, Haolin Zhang, Yingying Han, Zhengrong Yuan, Qiang Weng, Seasonal changes in the expression of PACAP, VPAC1, VPAC2, PAC1 and testicular activity in the testis of the muskrat (Ondatra zibethicus) , European Journal of Histochemistry: Vol. 66 No. 2 (2022)
- M Sereno, MA GarcÃa-Cabezas, J De Castro, P Cejas, E Casado Saenz, C Belda-Iniesta, J Barriuso Feijoo, J Larrauri, M Nistal, M Gonzalez Baron, Inmunohistochemical expression of p53, Bcl-2, COX-2, C-erb-B2, EPO-R, ?-catenin, and E-cadherin in non tumoral gastric mucous membrane , European Journal of Histochemistry: Vol. 50 No. 4 (2006)
- V. Matozzo, M. G. Marin, First cytochemical study of haemocytes from the crab Carcinus aestuarii (Crustacea, Decapoda) , European Journal of Histochemistry: Vol. 54 No. 1 (2010)
- Guest Editor: Mario Raspanti, the Italian Society For The Study Of Connective Tissues (SISC) Meeting, (SISC) Varese, 27-28 October 2011 , European Journal of Histochemistry: Vol. 55 No. s2 (2011): The Italian Society for the study of Connective Tissues (SISC) Meeting, (SISC)
<< < 31 32 33 34 35 36 37 38 39 40 > >>
You may also start an advanced similarity search for this article.
