Immunopositivity for Siglec-15 in gastric cancer and its association with clinical and pathological parameters

  • Michael Williams Leal Quirino Laboratório de Imunomodulação e Novas Abordagens Terapêuticas – LINAT / Núcleo de Pesquisa em Inovação Terapêutica Suely Galdino - NUPIT SG, Universidade Federal de Pernambuco, Recife, Brazil.
  • Michelly Cristiny Pereira Laboratório de Imunomodulação e Novas Abordagens Terapêuticas – LINAT / Núcleo de Pesquisa em Inovação Terapêutica Suely Galdino - NUPIT SG, Universidade Federal de Pernambuco, Recife, Brazil. https://orcid.org/0000-0002-1672-8202
  • Maria de Fátima Deodato de Souza Laboratório de Imunomodulação e Novas Abordagens Terapêuticas – LINAT / Núcleo de Pesquisa em Inovação Terapêutica Suely Galdino - NUPIT SG, Universidade Federal de Pernambuco, Recife, Brazil.
  • Ivan da Rocha Pitta Laboratório de Imunomodulação e Novas Abordagens Terapêuticas – LINAT / Núcleo de Pesquisa em Inovação Terapêutica Suely Galdino - NUPIT SG, Universidade Federal de Pernambuco, Recife, Brazil.
  • Antônio Felix da Silva Filho Laboratório de Imunomodulação e Novas Abordagens Terapêuticas – LINAT / Núcleo de Pesquisa em Inovação Terapêutica Suely Galdino - NUPIT SG, Universidade Federal de Pernambuco, Recife, Brazil.
  • Mario S. de Souza Albuquerque Laboratório de Imunomodulação e Novas Abordagens Terapêuticas – LINAT / Núcleo de Pesquisa em Inovação Terapêutica Suely Galdino - NUPIT SG, Universidade Federal de Pernambuco, Recife, Brazil.
  • Amanda Pinheiro de Barros Albuquerque Laboratório de Imunomodulação e Novas Abordagens Terapêuticas – LINAT / Núcleo de Pesquisa em Inovação Terapêutica Suely Galdino - NUPIT SG, Universidade Federal de Pernambuco, Recife, Brazil.
  • Mário Rino Martins Hospital do Câncer de Pernambuco - HCP, Recife PE, Brazil, Brazil.
  • Maira Galdino da Rocha Pitta Laboratório de Imunomodulação e Novas Abordagens Terapêuticas – LINAT / Núcleo de Pesquisa em Inovação Terapêutica Suely Galdino - NUPIT SG, Universidade Federal de Pernambuco, Recife, Brazil.
  • Moacyr Jesus Barreto de Melo Rêgo | moacyr.rego@gmail.com Laboratório de Imunomodulação e Novas Abordagens Terapêuticas – LINAT / Núcleo de Pesquisa em Inovação Terapêutica Suely Galdino - NUPIT SG, Universidade Federal de Pernambuco, Recife, Brazil. https://orcid.org/0000-0002-1883-6012

Abstract

The sialic acid-binding immunoglobulin-type lectin Siglec-15 is a promising target to cancer immunotherapy in several tumor types. The present study aimed to investigate Siglec-15 expression in gastric cancer (GC) patient tissue and to evaluate its clinical value. Siglec-15 expression was evaluated by immunohistochemistry with 71 patients. Siglec-15 staining was observed in tumor cells of 53 (74.64%) patients, with significant association with histologic classification and angiolymphatic invasion (p<0.05). Immunohistochemistry analysis also detected Siglec-15 in tumor-associated stroma cells (macrophages/myeloid cells). There was no significant association with outcomes parameters. Siglec-15 expression in well differentiated histological GC tissues and in the tumor microenvironment are potential targets to be further investigated as a novel prognostic factor for GC.

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Published
2021-03-04
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Articles
Ethics Approval
Ethical approval was obtained from the Human Ethics Committee of the Hospital do Câncer de Pernambuco (HCP) (CAAE: 39976214.90000.5205).
Supporting Agencies
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq).
Keywords:
siglec, sialic acid, immunohistochemistry, clinical-pathological analyses
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How to Cite
Quirino, M. W. L., Pereira, M. C., Deodato de Souza, M. de F., Pitta, I. da R., da Silva Filho, A. F., Albuquerque, M. S. de S., Albuquerque, A. P. de B., Martins, M. R., Pitta, M. G. da R., & Rêgo, M. J. B. de M. (2021). Immunopositivity for Siglec-15 in gastric cancer and its association with clinical and pathological parameters. European Journal of Histochemistry, 65(1). https://doi.org/10.4081/ejh.2021.3174