https://doi.org/10.4081/ejh.2021.3174

Immunopositivity for Siglec-15 in gastric cancer and its association with clinical and pathological parameters

Vol. 65 No. 1 (2021)
Submitted: 23 August 2020
Accepted: 9 February 2021
Published: 4 March 2021
siglec, sialic acid, immunohistochemistry, clinical-pathological analyses
Abstract Views: 1741
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Supplementary: 154
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Authors

Michael Williams Leal Quirino
Laboratório de Imunomodulação e Novas Abordagens Terapêuticas – LINAT / Núcleo de Pesquisa em Inovação Terapêutica Suely Galdino - NUPIT SG, Universidade Federal de Pernambuco, Recife, Brazil.
Michelly Cristiny Pereira
https://orcid.org/0000-0002-1672-8202
Laboratório de Imunomodulação e Novas Abordagens Terapêuticas – LINAT / Núcleo de Pesquisa em Inovação Terapêutica Suely Galdino - NUPIT SG, Universidade Federal de Pernambuco, Recife, Brazil.
Maria de Fátima Deodato de Souza
Laboratório de Imunomodulação e Novas Abordagens Terapêuticas – LINAT / Núcleo de Pesquisa em Inovação Terapêutica Suely Galdino - NUPIT SG, Universidade Federal de Pernambuco, Recife, Brazil.
Ivan da Rocha Pitta
Laboratório de Imunomodulação e Novas Abordagens Terapêuticas – LINAT / Núcleo de Pesquisa em Inovação Terapêutica Suely Galdino - NUPIT SG, Universidade Federal de Pernambuco, Recife, Brazil.
Antônio Felix da Silva Filho
Laboratório de Imunomodulação e Novas Abordagens Terapêuticas – LINAT / Núcleo de Pesquisa em Inovação Terapêutica Suely Galdino - NUPIT SG, Universidade Federal de Pernambuco, Recife, Brazil.
Mario S. de Souza Albuquerque
Laboratório de Imunomodulação e Novas Abordagens Terapêuticas – LINAT / Núcleo de Pesquisa em Inovação Terapêutica Suely Galdino - NUPIT SG, Universidade Federal de Pernambuco, Recife, Brazil.
Amanda Pinheiro de Barros Albuquerque
Laboratório de Imunomodulação e Novas Abordagens Terapêuticas – LINAT / Núcleo de Pesquisa em Inovação Terapêutica Suely Galdino - NUPIT SG, Universidade Federal de Pernambuco, Recife, Brazil.
Mário Rino Martins
Hospital do Câncer de Pernambuco - HCP, Recife PE, Brazil, Brazil.
Maira Galdino da Rocha Pitta
Laboratório de Imunomodulação e Novas Abordagens Terapêuticas – LINAT / Núcleo de Pesquisa em Inovação Terapêutica Suely Galdino - NUPIT SG, Universidade Federal de Pernambuco, Recife, Brazil.
Moacyr Jesus Barreto de Melo Rêgo
moacyr.rego@gmail.com
https://orcid.org/0000-0002-1883-6012
Laboratório de Imunomodulação e Novas Abordagens Terapêuticas – LINAT / Núcleo de Pesquisa em Inovação Terapêutica Suely Galdino - NUPIT SG, Universidade Federal de Pernambuco, Recife, Brazil.

The sialic acid-binding immunoglobulin-type lectin Siglec-15 is a promising target to cancer immunotherapy in several tumor types. The present study aimed to investigate Siglec-15 expression in gastric cancer (GC) patient tissue and to evaluate its clinical value. Siglec-15 expression was evaluated by immunohistochemistry with 71 patients. Siglec-15 staining was observed in tumor cells of 53 (74.64%) patients, with significant association with histologic classification and angiolymphatic invasion (p<0.05). Immunohistochemistry analysis also detected Siglec-15 in tumor-associated stroma cells (macrophages/myeloid cells). There was no significant association with outcomes parameters. Siglec-15 expression in well differentiated histological GC tissues and in the tumor microenvironment are potential targets to be further investigated as a novel prognostic factor for GC.

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Ethics Approval

Ethical approval was obtained from the Human Ethics Committee of the Hospital do Câncer de Pernambuco (HCP) (CAAE: 39976214.90000.5205).

Supporting Agencies

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq).

How to Cite

Quirino, M. W. L., Pereira, M. C., Deodato de Souza, M. de F., Pitta, I. da R., da Silva Filho, A. F., Albuquerque, M. S. de S., … Rêgo, M. J. B. de M. (2021). Immunopositivity for Siglec-15 in gastric cancer and its association with clinical and pathological parameters. European Journal of Histochemistry, 65(1). https://doi.org/10.4081/ejh.2021.3174

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