Heterotopic ossification in a patient with diffuse idiopathic skeletal hyperostosis: Input from histological findings

https://doi.org/10.4081/ejh.2020.3176

Authors

  • Caterina Licini Department of Clinical and Molecular Sciences-DISCLIMO, Università Politecnica delle Marche, Ancona, Italy. https://orcid.org/0000-0002-0018-8096
  • Luca Farinelli Department of Clinical and Molecular Sciences-DISCLIMO, Università Politecnica delle Marche, Ancona, Italy.
  • Giorgia Cerqueni Department of Clinical and Molecular Sciences-DISCLIMO, Università Politecnica delle Marche, Ancona, Italy. https://orcid.org/0000-0001-7390-7154
  • Andrell Hosein Department of Clinical and Molecular Sciences-DISCLIMO, Università Politecnica delle Marche, Ancona, Italy.
  • Saverio Marchi Department of Clinical and Molecular Sciences-DISCLIMO, Università Politecnica delle Marche, Ancona, Italy.
  • Antonio Gigante Department of Clinical and Molecular Sciences-DISCLIMO, Università Politecnica delle Marche, Ancona, Italy.
  • Monica Mattioli-Belmonte | m.mattioli@univpm.it Department of Clinical and Molecular Sciences-DISCLIMO, Università Politecnica delle Marche, Ancona, Italy. https://orcid.org/0000-0002-2087-2776

Abstract

A high incidence of heterotopic ossification (HO) has been reported in patients with diffuse idiopathic skeletal hyperostosis (DISH), a metabolic disease characterized by calcifications of entheses at spine and peripheral sites. We performed histological and immunohistochemical analyses in five different HO sites in a patient with DISH to study a possible mutual interaction of bone morphogenetic protein 2 (BMP-2), transforming growth factor beta (TGF-β), and decorin, crucial for bone mass increasing, matrix calcification, and endochondral bone formation. We speculated that the surgical trauma triggered HO, inducing TGF-β release at the lesion site. TGF-β recruits osteoblast precursor cells and determines the overexpression of BMP-2 in the surrounding skeletal muscle, inducing a further osteogenic differentiation, contributing to HO onset.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.

Downloads

Published
2020-12-03
Info
Issue
Section
Brief Reports
Keywords:
heterotopic ossification, DISH, BMP-2, TGF-beta, decorin
Statistics
  • Abstract views: 285

  • PDF: 162
  • HTML: 0
How to Cite
Licini, C., Farinelli, L., Cerqueni, G., Hosein, A., Marchi, S., Gigante, A., & Mattioli-Belmonte, M. (2020). Heterotopic ossification in a patient with diffuse idiopathic skeletal hyperostosis: Input from histological findings. European Journal of Histochemistry, 64(4). https://doi.org/10.4081/ejh.2020.3176