https://doi.org/10.4081/ejh.2021.3232

Potential effect of fish oil to preserve expression of cell cycle and tight junction regulating genes in colon after di-isononyl phthalate ingestion in albino Wistar rats

Vol. 65 No. 2 (2021)
Submitted: 16 February 2021
Accepted: 4 May 2021
Published: 31 May 2021
Di-isononyl phthalate, gastrointestinal tract, fish oil, tight junction, apoptosis
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Authors

Ahmed S. Ahmed
ahmedsahmed.tanta@gmail.com
https://orcid.org/0000-0002-8230-2795
Anatomy and Embryology Department, College of Medicine, Tanta University, Tanta, Egypt.
Hoda A. Ibrahim
Medical Biochemistry and Molecular Biology Department, College of Medicine, Tanta University, Tanta, Egypt.
Ehab M. Hantash
Anatomy and Embryology Department, College of Medicine, Tanta University, Tanta, Egypt.

Di-isononyl phthalate (DIP) is considered a high molecular-weight subtype of phthalates that are commonly used and could easily affect the gastrointestinal tract (GIT). Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are the main active components of fish oil (FO), and their anti-inflammatory potential was previously documented. The current study was designed to investigate the protective potential of fish oil against the impacts of DIP exposure on the colon of albino Wistar rats. Sixty albino Wistar rats were divided into Control group received corn oil for ten days. Di-isononyl phthalate treated group received DIP. Di-isononyl phthalate + fish oil treated group received both DIP and FO. FO was found to preserve the histological architecture, tight junction and cell cycle of the colon. In conclusion, the current study provided an evidence that FO has a protective potential against DIP further examinations to be done to fully understand the molecular basis of this potential as a step for further clinical applications.

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How to Cite

Ahmed, A. S., Ibrahim, H. A. ., & Hantash , E. M. (2021). Potential effect of fish oil to preserve expression of cell cycle and tight junction regulating genes in colon after di-isononyl phthalate ingestion in albino Wistar rats. European Journal of Histochemistry, 65(2). https://doi.org/10.4081/ejh.2021.3232

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