https://doi.org/10.4081/ejh.2022.3342
MiR-130a-5p contributed to the progression of endothelial cell injury by regulating FAS
Submitted: 12 October 2021
Accepted: 9 May 2022
Published: 31 May 2022
Accepted: 9 May 2022
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
MicroRNAs (miRNAs) play critical roles in the development of vascular diseases. However, the effects of miR-130a-5p and its functional targets on atherosclerosis (AS) are still largely unknown. In this regard, our aim is to explore the potentially important role of miR-130a-5p and its target gene during the progression of endothelial cell injury. We first found oxidized low-density lipoprotein (ox-LDL) induced FAS and cell apoptosis in HUVECs. Subsequently, miR-130a-5p expression was verified to be downregulated after ox-LDL treatment and negatively correlated with FAS, and FAS was identified as substantially upregulated in the ox-LDL-treated HUVEC cells. After that, the knockdown of FAS and overexpression of miR-130a-5p together were observed to aggregate ox-LDL-induced reduction of cell viability and apoptosis, cell cycle progression, cell proliferation, cell migration and invasion. In conclusion, we detected that miR-130a-5p contributed to the progression of endothelial cell injury by regulating of FAS, which may provide a new and promising therapeutic target for AS.
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How to Cite
Wang, W., Tang, W., Shan, E., Zhang, L., Chen, S., Yu, C., & Gao, Y. (2022). MiR-130a-5p contributed to the progression of endothelial cell injury by regulating FAS. European Journal of Histochemistry, 66(2). https://doi.org/10.4081/ejh.2022.3342
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