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LncRNA FBXO18-AS promotes gastric cancer progression by TGF-β1/Smad signaling

Authors

Yiming Zhang
wzzxyzym@163.com
https://orcid.org/0000-0002-1970-6367
Department of General Surgery, Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine, Wenzhou, China.
Wanqiong Zheng
Department of General Surgery, Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine, Wenzhou, China.
Liang Zhang
Department of Gastrointestinal Surgery, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Yechun Gu
Department of General Surgery, Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine, Wenzhou, China.
Lihe Zhu
Department of Pathology, Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine, Wenzhou, China.
Yingpeng Huang
Department of Gastrointestinal Surgery, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

For the digestive system, there exists one common malignant tumor, known as gastric cancer. It is the third most prevalent type of tumor among different tumors worldwide. It has been reported that long noncoding RNAs (lncRNAs), participate in various biological processes of gastric cancer. However, there are still many lncRNAs with unknown functions, and we discovered a novel lncRNA designated as FBXO18-AS. Whether lncRNAFBXO18-AS participates in gastric cancer progression is still unknown. Bioinformatic analysis, immunohistochemistry, Western blotting, and qPCR were carried out to explore FBXO18-AS and TGF-β1 expression. In addition, EdU, MTS, migration and transwell assays were performed to investigate the invasion, proliferation and migration of gastric cancer in vitro. We first discovered that FBXO18-AS expression was upregulated in gastric cancer and linked to poorer outcomes among patients with gastric cancer. Then, we confirmed that FBXO18-AS promoted the proliferation, invasion, migration, and an EMT-like process in gastric cancer in vivo and in vitro. Mechanistically, FBXO18-AS was found to be involved in the progression of gastric cancer by modulating TGF-β1/Smad signaling. Therefore, it might offer a possible biomarker for gastric cancer diagnosis and an effective strategy for clinical treatment.

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Ethics Approval

The study on human clinical specimens was approved and authorized by the Ethics Committee of Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine (protocol no. 2022-K067). Written informed consent was obtained from all enrolled patients, The Animal Care Committee of Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine approved the experiments on animals (protocol no. xmsq2022-0667)

Supporting Agencies

Public Welfare Technology Research Plan / Social Development Project of Zhejiang, China., Wenzhou Basic Science Research Project.

How to Cite

Zhang, Y., Zheng, W., Zhang, L., Gu, Y., Zhu, L., & Huang, Y. (2023). LncRNA FBXO18-AS promotes gastric cancer progression by TGF-β1/Smad signaling. European Journal of Histochemistry, 67(2). https://doi.org/10.4081/ejh.2023.3667
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