https://doi.org/10.4081/ejh.2024.3994
Pleural mesothelioma from fluoro-edenite exposure: PACAP and PAC1 receptor. A preliminary report
Submitted: 19 February 2024
Accepted: 19 March 2024
Published: 2 May 2024
Accepted: 19 March 2024
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
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Pleural mesothelioma is a devastating malignancy primarily associated with asbestos exposure. However, emerging evidence suggests that exposure to fluoro-edenite fibers, a naturally occurring mineral fiber, can also lead to the development of pleural mesothelioma. In this study, based on the hypothesis that pituitary adenylate cyclase-activating polypeptide (PACAP) and PACAP-preferring receptor (PAC1R) expressions could be dysregulated in pleural mesothelioma samples and that they could potentially act as diagnostic or prognostic biomarkers, we aimed to investigate the immunohistochemical expression of PACAP and PAC1R in pleural biopsies from patients with pleural mesothelioma exposed to fluoro-edenite fibers. A total of 12 patients were included in this study, and their biopsies were processed for immunohistochemical analysis to evaluate the expression of PACAP and its receptor. The study revealed a correlation between the overexpression of PACAP and PAC1R and shorter overall survival in patients with malignant mesothelioma. These findings suggest that PACAP and PAC1R expression levels could serve as potential prognostic biomarkers for malignant mesothelioma. Furthermore, the immunohistochemical analysis of PACAP and PAC1R may provide valuable information for clinicians to guide therapeutic decisions and identify patients with poorer prognosis.
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Supporting Agencies
Piano di Incentivi per la ricerca di Ateneo 2020/2022 Linea di intervento 2How to Cite
Lombardo, C., Maugeri, G., D’Amico, A. G., Broggi, G., Caltabiano, R., Filetti, V., … Loreto, C. (2024). Pleural mesothelioma from fluoro-edenite exposure: PACAP and PAC1 receptor. A preliminary report. European Journal of Histochemistry, 68(2). https://doi.org/10.4081/ejh.2024.3994
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