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Spinosin ameliorates osteoarthritis through enhancing the Nrf2/HO-1 signaling pathway
Osteoarthritis (OA) is a common degenerative joint disease in the elderly, while oxidative stress-induced chondrocyte degeneration plays a key role in the pathologic progression of OA. One possible reason is that the expression of nuclear factor erythroid 2-related factor 2 (Nrf2), which acts as the intracellular defense factor against oxidative stress, is significantly inhibited in chondrocytes. Spinosin (SPI) is a potent Nrf2 agonist, but its effect on OA is still unknown. In this study, we found that SPI can alleviate tert-Butyl hydroperoxide (TBHP)-induced extracellular matrix degradation of chondrocytes. Additionally, SPI can effectively activate Nrf2, heme oxygenase-1 (HO-1), and NADPH quinone oxidoreductase 1 (NQO1) in chondrocytes under the TBHP environment. When Nrf2 was silenced by siRNA, the cartilage protective effect of SPI was also weakened. Finally, SPI showed good alleviative effects on OA in mice. Thus, SPI can ameliorate oxidative stress-induced chondrocyte dysfunction and exhibit a chondroprotective effect through activating the Nrf2/HO-1 pathway, which may provide a novel and promising option for the treatment of OA.
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Ethics Approval
This study was approved by the Ethics Committee and the Institutional Animal Care and Use Committee of Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical SchoolSupporting Agencies
Changzhou Sci&Tech Program, Changzhou UniversityHow to Cite
Lu, P., Li, S., Zhang, C., Jiang, X., Xiang, J., Xu, H., … Shi, Y. (2024). Spinosin ameliorates osteoarthritis through enhancing the Nrf2/HO-1 signaling pathway. European Journal of Histochemistry, 68(2). https://doi.org/10.4081/ejh.2024.4033
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