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Restorative effects of camellia oil on the skin-barrier function in a model of DNCB-induced atopic dermatitis
This study aimed to evaluate the therapeutic efficacy of camellia oil on 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD) in mice, as well as its effect on the expression of skin-barrier-related proteins. A mouse model of AD was created via topical application of DNCB; subsequently, the animals were randomly divided into four groups: the blank control (Control), model (Model), moisturizing cream (Moisturizer), and camellia oil (Camellia) groups. The Camellia group received camellia oil, whereas the Moisturizer group was treated with moisturizing cream, as a positive control. Skin lesions, ear and back tissue morphology, and the serum levels of IgE, IL-4, and IFN-γ were analyzed. Compared with the Control group, AD mice exhibited erythema, papules, dryness, peeling, and significantly higher serum IgE and IL-4 levels. Compared with the Model group, treatment with camellia oil and moisturizing cream considerably reduced skin inflammation, ear thickness, and scratching frequency. A histopathological analysis revealed that camellia oil reduced inflammatory-cell infiltration and edema in the AD-affected skin. Furthermore, camellia oil upregulated filaggrin (FLG), thus aiding in skin-barrier repair. These findings suggest that camellia oil significantly improves AD symptoms, enhances FLG expression, and restores the damaged skin barrier in AD mouse models.
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the experiment was authorized by the Animal Ethics Committee of the Fifth people's Hospital of Hainan ProvinceSupporting Agencies
Hainan Province Clinical Medical Center , Hainan Provincial Natural Science Foundation of ChinaHow to Cite
Restorative effects of camellia oil on the skin-barrier function in a model of DNCB-induced atopic dermatitis. (2025). European Journal of Histochemistry, 69(1). https://doi.org/10.4081/ejh.2025.4147
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