https://doi.org/10.4081/ejh.2025.4147
Restorative effects of camellia oil on the skin-barrier function in a model of DNCB-induced atopic dermatitis
Submitted: 25 September 2024
Accepted: 10 December 2024
Published: 21 January 2025
Accepted: 10 December 2024
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
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This study aimed to evaluate the therapeutic efficacy of camellia oil on 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD) in mice, as well as its effect on the expression of skin-barrier-related proteins. A mouse model of AD was created via topical application of DNCB; subsequently, the animals were randomly divided into four groups: the blank control (Control), model (Model), moisturizing cream (Moisturizer), and camellia oil (Camellia) groups. The Camellia group received camellia oil, whereas the Moisturizer group was treated with moisturizing cream, as a positive control. Skin lesions, ear and back tissue morphology, and the serum levels of IgE, IL-4, and IFN-γ were analyzed. Compared with the Control group, AD mice exhibited erythema, papules, dryness, peeling, and significantly higher serum IgE and IL-4 levels. Compared with the Model group, treatment with camellia oil and moisturizing cream considerably reduced skin inflammation, ear thickness, and scratching frequency. A histopathological analysis revealed that camellia oil reduced inflammatory-cell infiltration and edema in the AD-affected skin. Furthermore, camellia oil upregulated filaggrin (FLG), thus aiding in skin-barrier repair. These findings suggest that camellia oil significantly improves AD symptoms, enhances FLG expression, and restores the damaged skin barrier in AD mouse models.
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Ethics Approval
the experiment was authorized by the Animal Ethics Committee of the Fifth people's Hospital of Hainan ProvinceSupporting Agencies
Hainan Province Clinical Medical Center , Hainan Provincial Natural Science Foundation of ChinaHow to Cite
Jiao, S., Deng, L., Niu, M., & Yang, J. (2025). Restorative effects of camellia oil on the skin-barrier function in a model of DNCB-induced atopic dermatitis. European Journal of Histochemistry, 69(1). https://doi.org/10.4081/ejh.2025.4147
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