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Nucleoli in large (giant) bi- and multinucleate cells after apoptosis-inducing photodynamic treatment

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K Smetana
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Z Hrkal
The present experimental study was undertaken to provide information on nucleolar changes accompanying the apoptotic process in large or giant binucleate and multinucleate cells (LBMNCs). Such cells were present in a small but constant percentage in cultures of HL-60 cells. The apoptotic process was induced by photodynamic treatment (PDT) by means of 5-aminolaevulinic acid (ALA) as the precursor of the photosensitizer protoporphyrin IX and irradiation with broad spectrum blue light (BL). Nucleolar changes in LBMNCs were characterized by marked reduction or disappearance of silver stained particles representing AgNORs in nucleoli including the large ones. In addition, PDT also significantly reduced the number of nucleoli regardless of their size. These changes apparently reflected the decrease or cessation of nucleolar biosynthetic activities and resembled those which were previously observed in naturally maturing bone marrow megakaryocytes (Janoutová et al., 2001).

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Karel Smetana, Pui K Chan, Yuri Marinov, Josef Souček, Zbyněk Hrkal, Harris Busch (2004)
A short note on the nucleolar size and density in apoptotic leukemic granulocytic precursors (HL-60 cells). Life Sciences, 75(7), 791.
10.1016/j.lfs.2003.12.028
Karel Smetana, Hana Klamová, Michaela Pluskalová, Petr Stöckbauer, Zbyněk Hrkal (2006)
To the intranucleolar translocation of AgNORs in leukemic early granulocytic and plasmacytic precursors. Histochemistry and Cell Biology, 125(1-2), 165.
10.1007/s00418-005-0059-z
Claudio Casali, Stella Siciliani, Lorena Zannino, Marco Biggiogera (2022)
Histochemistry for nucleic acid research: 60 years in the European Journal of Histochemistry. European Journal of Histochemistry, 66(2),
10.4081/ejh.2022.3409
Marco Biggiogera, Barbara Cisterna, Alessandro Spedito, Lorella Vecchio, Manuela Malatesta (2008)
Perichromatin fibrils as early markers of transcriptional alterations. Differentiation, 76(1), 57.
10.1111/j.1432-0436.2007.00211.x
Pavan Kumar Puvvula, Anne M. Moon (2021)
Novel Cell-Penetrating Peptides Derived From Scaffold-Attachment- Factor A Inhibits Cancer Cell Proliferation and Survival. Frontiers in Oncology, 11,
10.3389/fonc.2021.621825

How to Cite

Smetana, K., & Hrkal, Z. (2009). Nucleoli in large (giant) bi- and multinucleate cells after apoptosis-inducing photodynamic treatment. European Journal of Histochemistry, 47(1), 39–44. https://doi.org/10.4081/805

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