Nuclear microenvironments: an architectural platform for the convergence and integration of transcriptional regulatory signals

Published: 29 June 2009
Abstract Views: 320
PDF: 367
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

Functional interrelationships between the intranuclear organization of nucleic acids and regulatory proteins are obligatory for fidelity of transcriptional activation and repression. In this article, using the Runx/AML/Cbfa transcription factors as a paradigm for linkage between nuclear structure and gene expression we present an overview of growing insight into the dynamic organization and assembly of regulatory machinery for gene expression at microenvironments within the nucleus. We address contributions of nuclear microenvironments to the convergence and integration of regulatory signals that mediate transcription by supporting the combinatorial assembly of regulatory complexes.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.

Citations

How to Cite

Stein, G., Stein, J., Lian, J., & van Wijnen, A. (2009). Nuclear microenvironments: an architectural platform for the convergence and integration of transcriptional regulatory signals. European Journal of Histochemistry, 48(1), 65–76. https://doi.org/10.4081/860