https://doi.org/10.4081/894

Co-localization of P2Y1 receptor and NTPDase1/CD39 within caveolae in human placenta

Vol. 48 No. 3 (2004)
Published: 29 June 2009
Abstract Views: 425
PDF: 440
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

A Kittel
support@pagepress.org
Zs Csapó
E Csizmadia
SW Jackson
SC Robson
Nucleoside triphosphate diphosphohydrolase-1 (NTPDase1/ CD39) is the dominant ecto-nucleotidase of vascular and placental trophoblastic tissues and appears to modulate the functional expression of type-2 purinergic (P2) Gprotein coupled receptors (GPCRs). Hence, this ectoenzyme could regulate nucleotide-mediated signalling events in placental tissue. This immunohistochemical and immuno-electron microscopic study demonstrates the expression of NTPDase1/CD39, P2Y1 and P2Y2 receptors in different cell types of human placenta. Specifically P2Y1 has an exclusive vascular distribution whereas P2Y2 is localized on trophoblastic villi. Co-localization of P2Y1 and NTPDase1/ CD39 are observed in caveolae, membrane microdomains of endothelial cells. The differential localization of these P2 receptors might indicate their unique roles in the regulation of extracellular nucleotide concentrations in human placental tissues and consequent effects on vascular tone and blood fluidity.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.

Citations

Crossref
Scopus
Google Scholar
Europe PMC

How to Cite

Kittel, A., Csapó, Z., Csizmadia, E., Jackson, S., & Robson, S. (2009). Co-localization of P2Y1 receptor and NTPDase1/CD39 within caveolae in human placenta. European Journal of Histochemistry, 48(3), 253–260. https://doi.org/10.4081/894

PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.