https://doi.org/10.4081/910

Immunohistochemical detection of tyrosine kinase B (TrkB) in the enteric nervous system of the small intestine in pigeon (Columba livia)

Vol. 48 No. 4 (2004)
Published: 29 June 2009
Abstract Views: 379
PDF: 380
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Authors

A Germanà
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MB Levanti
DF Monjil
E Ciriaco
The presence and cell localization of TrkB, the main receptor for the neurotrophins (NTs), was investigated immunohistochemically in the small intestine of adult pigeons, with special reference to the enteric nervous system (ENS). Several neuronal (neurofilament proteins and PGP 9.5) and glial cell (S100 protein) markers were studied in parallel. TrkB immunoreactivity (TrkB-IR) was found to be restricted to immunohistochemically-identified glial cells present in the enteric plexuses, and to Schwann cells forming the perivascular plexus. Also, TrkB-IR was detected in enterochromaffin cells and in unidentified dendritic cells within the gut-associated lymphoid tissue. The present results demonstrate that as for mammals, TrkB in the ENS is restricted to the glial cells. The possible function of the TrkB ligands, however, remains to be established.

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How to Cite

Germanà, A., Levanti, M., Monjil, D., & Ciriaco, E. (2009). Immunohistochemical detection of tyrosine kinase B (TrkB) in the enteric nervous system of the small intestine in pigeon (Columba livia). European Journal of Histochemistry, 48(4), 373–376. https://doi.org/10.4081/910

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