https://doi.org/10.4081/966

Atrial natriuretic peptide secretion during development of the rat supraoptic nucleus

Vol. 49 No. 4 (2005)
Published: 30 June 2009
Abstract Views: 521
PDF: 385
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Authors

E Farina Lipari
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D Lipari
F Dieli
B Valentino
Since a relationship between atrial natriuretic peptide and oxytocin was recently demonstrated in the heart (Gutkowska et al., 1997), the aim of this study was to determine whether a relationship between the two peptides is present also in the rat hypothalamus. For this purpose, we measured ANPontogeny in the rat hypothalamus immunohistochemically and compared it with oxytocin-ontogeny which we previously studied. The results showed that the ANP-peptide and mRNA-ANP start at the 18th day of the fetal life. Our earlier data for oxytocin in the rat hypothalamus showed that only mRNA-oxytocin appeared the 18th day of foetal life (Farina Lipari et al., 2001); thus, at the 18th day of foetal life, mRNA-ANP, ANP-peptide and mRNA-oxytocin are present.We conclude that in the hypothalamus, differently from that in the heart, ANP might play a role on the synthesis of the oxytocin since ANP and its mRNA appear earlier than oxytocin.

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How to Cite

Farina Lipari, E., Lipari, D., Dieli, F., & Valentino, B. (2009). Atrial natriuretic peptide secretion during development of the rat supraoptic nucleus. European Journal of Histochemistry, 49(4), 379–384. https://doi.org/10.4081/966

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