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Koilocytes are enriched for alkaline-labile sites

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This study investigated possible variations in the chromatin structure of koilocytes resulting from human papillomavirus (HPV) infection. Alkaline-labile sites (ALS) were detected with the DNA breakage detection–fluorescence in situ hybridization (DBD-FISH) technique using a whole human genome DNA probe obtained from individuals without koilocytosis. The variable levels of ALS present were measured quantitatively using image analysis after whole-genome DNA hybridization. A significant increase in the number of ALS was observed in koilocytes compared with normal cells. We demonstrated that the presence of ALS could be an indicator of chromatin change in koilocytes caused by HPV infection.

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E. I. Cortés-Gutiérrez, Instituto Mexicano del Seguro Social
División de Genética. Centro de Investigación Biomédica del Noreste, Instituto Mexicano del Seguro Social
M. I. Dávila-Rodríguez, Instituto Mexicano del Seguro Social
División de Genética. Centro de Investigación Biomédica del Noreste, Instituto Mexicano del Seguro Social
J. L. Fernández, Complejo Hospitalario Universitario Juan Canalejo
Sección de Genética y Unidad de Investigación, Hospital Teresa Herrera, Complejo Hospitalario, Universitario Juan Canalejo
C. López-Fernández, Universidad Autónoma de Madrid
Universidad Autónoma de Madrid
J. Gosálvez, Universidad Autónoma de Madrid
Universidad Autónoma de Madrid

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Koilocytes are enriched for alkaline-labile sites. (2010). European Journal of Histochemistry, 54(4), e32. https://doi.org/10.4081/ejh.2010.e32