Immunoreactivity of thymosin beta 4 in human foetal and adult genitourinary tract

  • S. Nemolato | sonianemolato@libero.it Università di Cagliari, Italy.
  • T. Cabras Università di Cagliari, Italy.
  • M.U. Fanari Università di Cagliari, Italy.
  • F. Cau Università di Cagliari, Italy.
  • D. Fanni Università di Cagliari, Italy.
  • C. Gerosa Università di Cagliari, Italy.
  • B. Manconi Università di Cagliari, Italy.
  • I. Messana Università di Cagliari, Italy.
  • M. Castagnola Università Cattolica Roma, Italy.
  • G. Faa Università di Cagliari, Italy.

Abstract

Thymosins beta 4 (Tβ4) is a member of the beta-thymosins family, a family of peptides playing essential roles in many cellular functions. Our recent studies suggested Tβ4 plays a key role in the development of human salivary glands and the gastrointestinal tract. The aim of this study was to analyse the presence of Tβ4 in the human adult and foetal genitourinary tract. Immunolocalization of Tβ4 was studied in autoptic samples of kidney, bladder, uterus, ovary, testicle and prostate obtained from four human foetuses and four adults. Presence of the peptide was observed in cells of different origin: in surface epithelium, in gland epithelial cells and in the interstitial cells. Tβ4 was mainly found in adult and foetal bladder in the transitional epithelial cells; in the adult endometrium, glands and stromal cells were immunoreactive for the peptide; Tβ4 was mainly localized in the glands of foetal prostate while, in the adults a weak Tβ4 reactivity was restricted to the stroma. In adult and foetal kidney, Tβ4 reactivity was restricted to ducts and tubules with completely spared glomeruli; a weak positivity was observed in adult and foetal oocytes; immunoreactivity was mainly localized in the interstitial cells of foetal and adult testis. In this study, we confirm that Tβ4 could play a relevant role during human development, even in the genitourinary tract, and reveal that immunoreactivity for this peptide may change during postnatal and adult life.

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Author Biographies

S. Nemolato, Università di Cagliari
Dipartimento di Citomorfologia, Divisione di Anatomia Patologica
T. Cabras, Università di Cagliari
Dipartimento di Scienze Applicate ai Biosistemi
M.U. Fanari, Università di Cagliari
Dipartimento di Citomorfologia, Divisione di Anatomia Patologica
F. Cau, Università di Cagliari
Dipartimento di Citomorfologia, Divisione di Anatomia Patologica
D. Fanni, Università di Cagliari
Dipartimento di Citomorfologia, Divisione di Anatomia Patologica
C. Gerosa, Università di Cagliari
Dipartimento di Scienze Applicate ai Biosistemi
B. Manconi, Università di Cagliari
Dipartimento di Scienze Applicate ai Biosistemi
I. Messana, Università di Cagliari
Dipartimento di Scienze Applicate ai Biosistemi
M. Castagnola, Università Cattolica Roma
Istituto di Biochimica e di Biochimica Clinica
G. Faa, Università di Cagliari
Dipartimento di Citomorfologia, Divisione di Anatomia Patologica
Published
2010-10-13
Section
Original Papers
Supporting Agencies
Fondazione Banco di Sardegna, Cagliary, Italy
Keywords:
Thymosin ?4, genitourinary tract, development
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How to Cite
Nemolato, S., Cabras, T., Fanari, M., Cau, F., Fanni, D., Gerosa, C., Manconi, B., Messana, I., Castagnola, M., & Faa, G. (2010). Immunoreactivity of thymosin beta 4 in human foetal and adult genitourinary tract. European Journal of Histochemistry, 54(4), e43. https://doi.org/10.4081/ejh.2010.e43