Structural and functional alterations of the cell nucleus in skeletal muscle wasting: the evidence in situ

Submitted: 8 September 2010
Accepted: 9 September 2010
Published: 19 October 2010
Abstract Views: 1008
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The histochemical and ultrastructural analysis of the nuclear components involved in RNA transcription and splicing can reveal the occurrence of cellular dysfunctions eventually related to the onset of a pathological phenotype. In recent years, nuclear histochemistry at light and electron microscopy has increasingly been used to investigate the basic mechanisms of skeletal muscle diseases; the study in situ of nuclei of myofibres and satellite cells proved to be crucial for understanding the pathogenesis of skeletal muscle wasting in sarcopenia, myotonic dystrophy and laminopathies. 

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Malatesta, M., & Meola, G. (2010). Structural and functional alterations of the cell nucleus in skeletal muscle wasting: the evidence in situ. European Journal of Histochemistry, 54(4), e44. https://doi.org/10.4081/ejh.2010.e44