Differential expression of KCNQ1 K+ channel in tubular cells of frog kidney

  • S. Ćirović University of Belgrade, .
  • J. Marković-Lipkovski | acal@matf.bg.ac.rs University of Belgrade, .
  • J. Todorović University of Belgrade, .
  • J. NeÅ¡ović-Ostojić University of Belgrade, .
  • M. Jović Military Medical Academy, Belgrade, .
  • S. Ilić Military Medical Academy, Belgrade, .
  • S. Tatić University of Belgrade, .
  • D. ÄŒemerikić University of Belgrade, .


The aim of this study was to evaluate KCNQ1 K+ channel expression in the frog kidney of Rana esculenta. KCNQ1 K+ channel, also known as KvLQT1, is the pore forming a-subunit of the IKs K+ channel, a delayed rectifier voltage-gated K+ channel, which has an important role in water and salt transport in the kidney and gastrointestinal tract. The expression of KCNQ1 K+ channel along tubular epithelium differs from species to species. In the present study the expression of KCNQ1 K+ channel in the frog kidney has been demonstrated by immunohistochemistry. The presence of KCNQ1 K+ channel was demonstrated in the epithelial cells of distal convoluted tubule and collecting duct. However, the pattern of expression of KCNQ1 K+ channel differs between distal convoluted tubules and collecting duct. All epithelial cells of distal convoluted tubules revealed basolateral expression of KCNQ1 K+ channel. On the contrary, only the single cells of collecting duct, probably intercalated cells, showed diffuse cell surface staining with antibodies against KCNQ1 K+ channel. These findings suggest that KCNQ1 K+ channel has cell-specific roles in renal potassium ion transport.


Download data is not yet available.

Author Biography

J. Marković-Lipkovski, University of Belgrade
Institute of Pathology, Faculty of Medicine
Original Papers
Supporting Agencies
Ministry of Science and Technological Development of the Republic of Serbia.
KCNQ1 K channel, Rana esculenta, frog kidney, immunohistochemistry
Abstract views: 481

PDF: 113
HTML: 3560
Share it

PlumX Metrics

PlumX Metrics provide insights into the ways people interact with individual pieces of research output (articles, conference proceedings, book chapters, and many more) in the online environment. Examples include, when research is mentioned in the news or is tweeted about. Collectively known as PlumX Metrics, these metrics are divided into five categories to help make sense of the huge amounts of data involved and to enable analysis by comparing like with like.

How to Cite
Ćirović, S., Marković-Lipkovski, J., Todorović, J., Nešović-Ostojić, J., Jović, M., Ilić, S., Tatić, S., & Čemerikić, D. (2010). Differential expression of KCNQ1 K+ channel in tubular cells of frog kidney. European Journal of Histochemistry, 54(1), e7. https://doi.org/10.4081/ejh.2010.e7