18
2
9
0
Smart Citations
18
2
9
0
Citing PublicationsSupportingMentioningContrasting
View Citations

See how this article has been cited at scite.ai

scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.

Endothelial cell apoptosis in brown adipose tissue of rats induced by hyperinsulinaemia: the possible role of TNF-α

Authors

The aim of the present study was to investigate whether hyperinsulinaemia, which frequently precedes insulin resistance syndrome (obesity, diabetes), induces apoptosis of endothelial cells (ECs) in brown adipose tissue (BAT) and causes BAT atrophy and also, to investigate the possible mechanisms underlying ECs death. In order to induce hyperinsulinaemia, adult male rats of Wistar strain were treated with high dose of insulin (4 U/kg, intraperitonealy) for one or three days. Examinations at ultrastructural level showed apoptotic changes of ECs, allowing us to point out that changes mainly but not exclusively, occur in nuclei. Besides different stages of condensation and alterations of the chromatin, nuclear fragmentation was also observed. Higher number of ECs apoptotic nuclei in the BAT of hyperinsulinaemic rats was also confirmed by propidium iodide staining. Immunohistochemical localization of tumor necrosis factor-alpha (TNF-α) revealed increased expression in ECs of BAT of hyperinsulinaemic animals, indicating its possible role in insulin-induced apoptotic changes. These results suggest that BAT atrophy in hyperinsulinaemia is a result of endothelial and adipocyte apoptosis combined, rather than any of functional components alone.

Dimensions

Altmetric

PlumX Metrics

Plum Print visual indicator of research metrics
  • Citations
    • Citation Indexes: 22
  • Captures
    • Readers: 19
see details

Downloads

Publication Facts

Metric
This article
Other articles
Peer reviewers 
2
2.4

Reviewer profiles  N/A

Author statements

Author statements
This article
Other articles
Data availability 
N/A
16%
External funding 
N/A
32%
Competing interests 
N/A
11%
Metric
This journal
Other journals
Articles accepted 
57%
33%
Days to publication 
227
145

Indexed in

Editor & editorial board
profiles
Academic society 
N/A

PFL

1 2 3 4 5
Not useful Very useful

Citations

M. Markelic, University of Belgrade
Faculty of Biology, Centre for Electron Microscopy
K. Velickovic, University of Belgrade
Faculty of Biology, Centre for Electron Microscopy
I. Golic, University of Belgrade
Faculty of Biology, Centre for Electron Microscopy
V. Otasevic, University of Belgrade
Institute for Biological Research “Sinisa Stankovic"
A. Stancic, University of Belgrade
Institute for Biological Research “Sinisa Stankovic"
A. Jankovic, University of Belgrade
Institute for Biological Research “Sinisa Stankovic"
M. Vucetic, University of Belgrade
Institute for Biological Research “Sinisa Stankovic"
B. Buzadzic, University of Belgrade
Institute for Biological Research “Sinisa Stankovic"
B. Korac, University of Belgrade
Institute for Biological Research “Sinisa Stankovic"
A. Korac, Faculty of Biology
Faculty of Biology, Centre for Electron Microscopy

How to Cite

Markelic, M., Velickovic, K., Golic, I., Otasevic, V., Stancic, A., Jankovic, A., … Korac, A. (2011). Endothelial cell apoptosis in brown adipose tissue of rats induced by hyperinsulinaemia: the possible role of TNF-α. European Journal of Histochemistry, 55(4), e34. https://doi.org/10.4081/ejh.2011.e34

Similar Articles

<< < 65 66 67 68 69 70 71 72 73 74 > >> 

You may also start an advanced similarity search for this article.