MUC1 marks collecting tubules, renal vesicles, comma- and S-shaped bodies in human developing kidney

  • D. Fanni | fandan73@yahoo.it
  • N. Iacovidou
  • A. Locci
  • C. Gerosa
  • S. Nemolato
  • P. Van Eyken
  • G. Monga
  • S. Mellou Aretaieio Hospital, Greece.
  • G. Faa
  • V. Fanos

Abstract

MUC1 is a transmembrane glycoprotein, apically expressed in most epithelial cells, used in the differential diagnosis of carcinomas and for discrimination of tumors of non-epithelial origin showing epithelioid features. Little attention has been paid so far though, on its possible significance in embryonic tissues. A preliminary study from our group revealed MUC1 expression in the cap mesenchymal cells during human nephrogenesis, suggesting a role for MUC1 in the process of mesenchymal-to-epithelial transition. This study aimed at investigating the expression pattern of MUC1 in various developing structures of human fetal kidney. Expression of MUC1 was examined in kidneys of 5 human fetuses. MUC1 immunoreactivity was detected in ureteric bud tips, in collecting tubules, in cap mesenchymal cells undergoing the initial phases of mesenchymal-to-epithelial transition, in renal vesicles, comma-bodies, and S-shaped bodies. Our previous preliminary report suggested a role for MUC1 in the initial phases of the process of mesenchymal-to-epithelial transition. The present data suggest that MUC1 expression characterizes multiple structures during human nephrogenesis, from the ureteric bud, to the initial phases of mesenchymal-to-epithelial transition and that MUC1 should be added to the genes activated during the process of mesenchymal-to-epithelial transition in the cap mesenchyme of human kidney.

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Author Biography

S. Mellou, Aretaieio Hospital
Department of Pathology
Published
2012-10-26
Section
Original Papers
Keywords:
MUC1, immunohistochemistry, fetal kidney, nephrogenesis, renal vesicles, comma and S-shaped bodies, collecting tubules
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How to Cite
Fanni, D., Iacovidou, N., Locci, A., Gerosa, C., Nemolato, S., Van Eyken, P., Monga, G., Mellou, S., Faa, G., & Fanos, V. (2012). MUC1 marks collecting tubules, renal vesicles, comma- and S-shaped bodies in human developing kidney. European Journal of Histochemistry, 56(4), e40. https://doi.org/10.4081/ejh.2012.e40

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