Histochemical localization of sialic acids and antimicrobial substances in eccrine glands of porcine snout skin

  • K. Fukui Department of Veterinary Anatomy, College of Bioresource Sciences, Nihon University, 1866, Fujisawa; Kanagawa, Japan.
  • T. Yasui Department of Veterinary Anatomy, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa, Kanagawa, Japan.
  • H. Gomi Department of Veterinary Anatomy, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa, Kanagawa, Japan.
  • H. Sugiya Laboratory of Veterinary Biochemistry, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa, Kanagawa, Japan.
  • O. Fujimori Laboratory of Anatomy and Histochemistry, Faculty of Rehabilitation Science, Nagoya Gakuin University, 1350 Kamishinanocho, Seto Aichi, Japan.
  • W. Meyer Institute for Anatomy, University of Veterinary Medicine Hannover Foundation, Germany.
  • A. Tsukise | tsukise@brs.nihon-u.ac.jp Department of Veterinary Anatomy, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa, Kanagawa, Japan.

Abstract

The distribution of sialic acids and antimicrobial products (lysozyme, IgA, lactoferrin, β-defensin 2) as well as Rab3D in the eccrine glands of porcine snout skin was studied by sialoglycoconjugate histochemistry and immunohistochemistry. The secretory epithelium consisted of two types of secretory cells: dark and clear cells. The dark cells exhibited considerable amounts of sialoglycoconjugates, which included O-acetylated sialic acids, whereas sialic acids in the sequence Siaα2-3Gal1-4GlcNAc were confined to some of the dark cells. All antimicrobial substances and Rab3D were demonstrated to be also mainly present in some of the dark cells. Additionally, in the cytological and cytochemical features, the different characteristics were observed among the dark cells. The results obtained are discussed with regard to the functional significance of the eccrine glands. The secretory products elaborated by this gland type may function as protective agents in order to preserve the skin integrity of the snout region, considering that sialic acids and antimicrobial substances are important in general defense mechanisms.

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Published
2012-02-09
Section
Original Papers
Keywords:
sialic acids, antimicrobial substances, eccrine glands, porcine snout skin, histochemistry
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How to Cite
Fukui, K., Yasui, T., Gomi, H., Sugiya, H., Fujimori, O., Meyer, W., & Tsukise, A. (2012). Histochemical localization of sialic acids and antimicrobial substances in eccrine glands of porcine snout skin. European Journal of Histochemistry, 56(1), e6. https://doi.org/10.4081/ejh.2012.e6