NADPH-d activity in rat thymus after the application of retinoid acid

  • F. Dorko | frantisek.dorko@upjs.sk Pavol Jozef Safarik University in Kosice, Slovakia.
  • T. Å pakovská Pavol Jozef Safarik University in Kosice, Slovakia.
  • K. Lovasová Pavol Jozef Safarik University in Kosice, Slovakia.
  • P. Patlevič University of Ostrava, Czechia.
  • D. Kluchová Pavol Jozef Safarik University in Kosice, Slovakia.

Abstract

The aim of this work was to determine the localization of nicotinamide-adenine dinucleotide phosphate-diaphorase (NADPH-d) activity as the marker for synthesis of nitric oxide synthase (NOS) in the rat thymus after the application of retinoid acid (RA) on 1st, 7th, 14th and 21st days of gestation. The given results can build the basis for understanding of the role of NOS in rat thymus. NADPH-d positive cells were represented with dark-blue color and were localized on corticomedullar junction of the thymus. These cells were of different intensity of coloring and were shaped in oval, circle or irregular forms. NADPH-d positive nerve fibers were observed in perivascular topography. They were marked more strongly in the case of control group. The result of application of RA to gravid rats was that the birth weights of newborn rats and their thymuses were smaller, but without statistically significance.

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Author Biographies

F. Dorko, Pavol Jozef Safarik University in Kosice
Institute of Anatomy, Faculty of Medicine
T. Špakovská, Pavol Jozef Safarik University in Kosice
Department of Anatomy, Faculty of Medicine
K. Lovasová, Pavol Jozef Safarik University in Kosice
Department of Anatomy, Faculty of Medicine
P. Patlevič, University of Ostrava
Department of Anatomy, Faculty of Medicine
D. Kluchová, Pavol Jozef Safarik University in Kosice
Department of Anatomy, Faculty of Medicine
Published
2012-02-08
Section
Original Papers
Keywords:
nicotinamide-adenine dinucleotide phosphate-diaphorase, nitric oxide, retinoid acid, rat, thymus
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How to Cite
Dorko, F., Špakovská, T., Lovasová, K., PatlevičP., & Kluchová, D. (2012). NADPH-d activity in rat thymus after the application of retinoid acid. European Journal of Histochemistry, 56(1), e7. https://doi.org/10.4081/ejh.2012.e7