Immunoreactivity for thymosin beta 4 and thymosin beta 10 in the adult rat oro-gastro-intestinal tract

  • S. Nemolato | sonianemolato@libero.it Università di Cagliari, Italy.
  • J. Ekstrom University of Gothenburg, Sweden.
  • T. Cabras Università di Cagliari, Italy.
  • C. Gerosa Università di Cagliari, Italy.
  • D. Fanni Università di Cagliari, Italy.
  • E. Di Felice Università di Cagliari, Italy.
  • A. Locci Università di Cagliari, Italy.
  • I. Messana Università di Cagliari, Italy.
  • M. Castagnola Università Cattolica di Roma, Italy.
  • G. Faa Università di Cagliari, Italy.

Abstract

Thymosin beta 4 (Tβ4) and thymosin beta 10 (Tβ10) are two members of the β-thymosin family, involved in multiple cellular activities in different organs in multiple animal species. Here we report the expression pattern of Tβ4 and Tβ10 in rat tissues, in the gut and in annexed glands. The two peptide were differently expressed: Tβ4 was absent in salivary glands whereas Tβ10 was expressed in parotid and in submandibular glands. Tβ4 was mildly expressed in the tongue and in the oesophagus, where Tβ10 was absent. A similar expression was found in the stomach, ileum and colon mucosa. In pancreas Tβ4 reactivity was restricted to the Langerhans islet cells; Tβ4 was also detected in the exocrine cells. Both peptide were not expressed in liver cells. When the rat expression pattern in rat organs was compared to reactivity for Tβ4 and Tβ10 in humans, marked differences were found. Our data clearly indicate a species-specific expression of Tβ4 and Tβ10, characterized by the actual unpredictability of the expression of these peptides in different cells and tissues. The common high expression of Tβ4 in mast cells, both in humans and in rats, represents one of the few similarities between these two species.

Downloads

Download data is not yet available.

Author Biographies

S. Nemolato, Università di Cagliari
Istituto di Anatomia Patologica, Dipartimento di Scienze Chirurgiche, PO S. Giovanni di Dio
J. Ekstrom, University of Gothenburg
Division of Pharmacology, Institute of Neuroscience and Physiology, Sahlgrenska Academy
T. Cabras, Università di Cagliari
Dipartimento di  Scienze della Vita e dell’Ambiente
C. Gerosa, Università di Cagliari
Istituto di Anatomia Patologica, Dipartimento di Scienze Chirurgiche, PO S. Giovanni di Dio
D. Fanni, Università di Cagliari
Istituto di Anatomia Patologica, Dipartimento di Scienze Chirurgiche, PO S. Giovanni di Dio
E. Di Felice, Università di Cagliari
Istituto di Anatomia Patologica, Dipartimento di Scienze Chirurgiche, PO S. Giovanni di Dio
A. Locci, Università di Cagliari
Istituto di Anatomia Patologica, Dipartimento di Scienze Chirurgiche, PO S. Giovanni di Dio
I. Messana, Università di Cagliari
Dipartimento di  Scienze della Vita e dell’Ambiente
M. Castagnola, Università Cattolica di Roma
Istituto di Biochimica e Biochimica Clinica, Facoltà di Medicina
G. Faa, Università di Cagliari
Istituto di Anatomia Patologica, Dipartimento di Scienze Chirurgiche, PO S. Giovanni di Dio
Published
2013-05-07
Section
Original Papers
Supporting Agencies
Fondazione Banco di Sardegna - P.O.R. Sardegna F.S.E. Operational Programme of the Autonomous Region of Sardinia, European Social Fund 2007-2013
Keywords:
rats, thymosin beta 4, thymosin beta 10, immunohistochemistry, gastrointestinal tract
Statistics
Abstract views: 1621

PDF: 209
HTML: 502
Share it

PlumX Metrics

PlumX Metrics provide insights into the ways people interact with individual pieces of research output (articles, conference proceedings, book chapters, and many more) in the online environment. Examples include, when research is mentioned in the news or is tweeted about. Collectively known as PlumX Metrics, these metrics are divided into five categories to help make sense of the huge amounts of data involved and to enable analysis by comparing like with like.

How to Cite
Nemolato, S., Ekstrom, J., Cabras, T., Gerosa, C., Fanni, D., Di Felice, E., Locci, A., Messana, I., Castagnola, M., & Faa, G. (2013). Immunoreactivity for thymosin beta 4 and thymosin beta 10 in the adult rat oro-gastro-intestinal tract. European Journal of Histochemistry, 57(2), e17. https://doi.org/10.4081/ejh.2013.e17

Most read articles by the same author(s)