Immunoreactivity for thymosin beta 4 and thymosin beta 10 in the adult rat oro-gastro-intestinal tract
AbstractThymosin beta 4 (TÎ²4) and thymosin beta 10 (TÎ²10) are two members of the Î²-thymosin family, involved in multiple cellular activities in different organs in multiple animal species. Here we report the expression pattern of TÎ²4 and TÎ²10 in rat tissues, in the gut and in annexed glands. The two peptide were differently expressed: TÎ²4 was absent in salivary glands whereas TÎ²10 was expressed in parotid and in submandibular glands. TÎ²4 was mildly expressed in the tongue and in the oesophagus, where TÎ²10 was absent. A similar expression was found in the stomach, ileum and colon mucosa. In pancreas TÎ²4 reactivity was restricted to the Langerhans islet cells; TÎ²4 was also detected in the exocrine cells. Both peptide were not expressed in liver cells. When the rat expression pattern in rat organs was compared to reactivity for TÎ²4 and TÎ²10 in humans, marked differences were found. Our data clearly indicate a species-specific expression of TÎ²4 and TÎ²10, characterized by the actual unpredictability of the expression of these peptides in different cells and tissues. The common high expression of TÎ²4 in mast cells, both in humans and in rats, represents one of the few similarities between these two species.
PlumX Metrics provide insights into the ways people interact with individual pieces of research output (articles, conference proceedings, book chapters, and many more) in the online environment. Examples include, when research is mentioned in the news or is tweeted about. Collectively known as PlumX Metrics, these metrics are divided into five categories to help make sense of the huge amounts of data involved and to enable analysis by comparing like with like.
Copyright (c) 2013 S. Nemolato, J. Ekstrom, T. Cabras, C. Gerosa, D. Fanni, E. Di Felice, A. Locci, I. Messana, M. Castagnola, G. Faa
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.