Expression patterns of α2,3-Sialyltransferase I and α2,6-Sialyltransferase I in human cutaneous epithelial lesions

  • S.A. Ferreira | steffany.aferreira@gmail.com
  • J.L.A. Vasconcelos
  • R.C.W.C. Silva
  • C.L.B. Cavalcanti
  • C.L. Bezerra
  • M.J.B.M. Rêgo
  • E.I.C. Beltrão

Abstract

Skin tumors have become one of the most common cancers in the world and their carcinogenesis is frequently associated with altered glycosylation patterns. The aberrant sialylation, a type of glycosylation, can mediate pathophysiological key events during various stages of tumor progression, including invasion and metastasis. Sialyltransferases play a key role in a variety of biological processes, including cell-cell communication, cell–matrix interaction, adhesion, and protein targeting. In this study, it was evaluated the expression of ST3Gal I and ST6Gal I in cutaneous epithelial lesions that include actinic keratosis (n=15), keratoacanthoma (n=9), squamous cell carcinoma (n=22) and basal cell carcinoma (n=28) in order to evaluate if sialyltransferases expression is different in premalignant and in malignant tumors. The expression of ST3Gal I was observed in actinic keratosis (53%), keratoacanthoma (78%), squamous cell carcinoma (73%) and basal cell carcinoma (32%) with statistic differences between basal cell carcinoma and keratoacanthoma (P=0.0239) and basal cell carcinoma and squamous cell carcinoma (P=0.0096); for ST6Gal I, cytoplasmic expression was noted in actinic keratosis (40%), heterogeneous and cytoplasmic expression was noted in keratoacanthoma (67%), squamous cell carcinoma (41%) and basal cell carcinoma (7%) with statistic differences between basal cell carcinoma and squamous cell carcinoma (P=0.0061) and basal cell carcinoma and keratoacanthoma (P=0.0008). In summary, our results showed that the high expression of ST3Gal I and ST6Gal I, in skin tumors, is associated with tumors with greater potential for invasion and metastasis, as in the case of squamous cell carcinoma, and this may be related to their behavior.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.
Published
2013-02-14
Info
Issue
Section
Original Papers
Supporting Agencies
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Fundação de Amparo de Ciência e Tecnologia do Estado de Pernambuco (FACEPE)
Keywords:
sialic acid, α2, 3-sialyltransferases, 6-sialyltransferases, basal cell carcinoma, squamous cell carcinoma, actinic keratosis, keratoacanthoma
Statistics
  • Abstract views: 567

  • PDF: 313
  • HTML: 219
How to Cite
Ferreira, S., Vasconcelos, J., Silva, R., Cavalcanti, C., Bezerra, C., Rêgo, M., & BeltrãoE. (2013). Expression patterns of α2,3-Sialyltransferase I and α2,6-Sialyltransferase I in human cutaneous epithelial lesions. European Journal of Histochemistry, 57(1), e7. https://doi.org/10.4081/ejh.2013.e7