@article{Pirrone_Chiaravalli_Marando_Conti_Rainero_Pistochini_Lo Curto_Pasquali_Castelnuovo_Capella_Porta_2017, title={OTX1 and OTX2 as possible molecular markers of sinonasal carcinomas and olfactory neuroblastomas}, volume={61}, url={https://www.ejh.it/ejh/article/view/2730}, DOI={10.4081/ejh.2017.2730}, abstractNote={<p><em>OTX</em><strong> </strong>Homeobox genes are involved in embryonic morphogenesis and in the development of olfactory epithelium in adult. Mutations occurring in the <em>OTX </em>genes are reported to be associated to tumorigenisis in human. No reports correlate the expression of <em>OTX</em> genes and neoplasms of the nasal cavity. Thus, through immunohistochemical and Real-time PCR analysis we investigated <em>OTX1</em> and <em>OTX2</em> expression in the more frequent types of nasal and sinonasal tumours. Variable expression of both genes were found in normal sinonasal mucosa and in tumours. Interestingly, no expression of both <em>OTX </em>genes were detected in sinonasal intestinal-type adenocarcinomas; only <em>OTX1</em> was found in non-intestinal-type adenocarcinomas and <em>OTX2 </em>was selectively expressed in olfactory neuroblastomas. In conclusion, <em>OTX1</em> and <em>OTX2</em> genes might have a role in the pathogenesis of different types of sinonasal neoplasms.</p>}, number={1}, journal={European Journal of Histochemistry}, author={Pirrone, Cristina and Chiaravalli, Anna M. and Marando, Alessandro and Conti, Andrea and Rainero, Alessia and Pistochini, Andrea and Lo Curto, Francesco and Pasquali, Francesco and Castelnuovo, Paolo and Capella, Carlo and Porta, Giovanni}, year={2017}, month={Feb.} }