@article{Loreto_Filetti_Almeida_La Rosa_Leonardi_Grippaudo_Lo Giudice_2020, title={MMP-7 and MMP-9 are overexpressed in the synovial tissue from severe temporomandibular joint dysfunction }, volume={64}, url={https://www.ejh.it/ejh/article/view/3113}, DOI={10.4081/ejh.2020.3113}, abstractNote={<p>Matrix metalloproteinases (MMPs) are tissue-enzymes that play a key role during the remodeling process, such as in inflammatory diseases. MMP-7 and MMP-9 have been shown to be implicated in extracellular matrix homeostasis and in joint disc remodeling. The objective of this study was to determine the relation of MMP-7 and MMP-9 expression with severe temporomandibular joint dysfunction, in particular with anterior disk displacement without reduction (ADDwoR), using an immunohistochemical approach. Therefore, twenty human temporomandibular synovia in the test group and ten in the control group were collected. The results showed there was a statistically significant difference (P<0.001) for morphometric and densitometric analysis of both detected MMPs in control and test groups. In conclusion, MMP-7 and MMP-9 were overexpressed in the synovial tissue of patients with ADDwoR.</p>}, number={2}, journal={European Journal of Histochemistry}, author={Loreto, Carla and Filetti, Vera and Almeida, Luis Eduardo and La Rosa, Giusy Rita Maria and Leonardi , Rosalia and Grippaudo , Cristina and Lo Giudice, Antonino}, year={2020}, month={Apr.} }