TY - JOUR AU - Guarnieri, Giulia AU - Becatti, Matteo AU - Comeglio, Paolo AU - Vignozzi, Linda AU - Maggi, Mario AU - Vannelli, Gabriella Barbara AU - Morelli, Annamaria PY - 2021/08/13 Y2 - 2024/03/29 TI - Benzo[a]pyrene impairs the migratory pattern of human gonadotropin-releasing-hormone-secreting neuroblasts JF - European Journal of Histochemistry JA - Eur J Histochem VL - 65 IS - s1 SE - Articles DO - 10.4081/ejh.2021.3282 UR - https://www.ejh.it/ejh/article/view/3282 SP - AB - <p>Benzo[a]pyrene (BaP) is a widespread pollutant that can act as an endocrine disrupting compound (EDC) and interferes with reproductive function. The central regulatory network of the reproductive system is mediated by gonadotropin-releasing hormone (GnRH) neurons, which originate in the olfactory placode and, during ontogenesis, migrate into the hypothalamus. Given the importance of the migratory process for GnRH neuron maturation, we investigated the effect of BaP (10 µM for 24 h) on GnRH neuroblasts isolated from the human fetal olfactory epithelium (FNCB4). BaP exposure significantly reduced the mRNA level of genes implicated in FNCB4 cell migration and affected their migratory ability. Our findings demonstrate that BaP may interfere with the central neuronal network controlling human reproduction affecting GnRH neuron maturation.</p> ER -